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左诺曲朵用于治疗化疗引起的恶心和呕吐。

Levonantradol for the treatment of chemotherapy-induced nausea and vomiting.

作者信息

Gerhartz H H, Binsack T, Hiller E

出版信息

Klin Wochenschr. 1983 Jul 15;61(14):719-21. doi: 10.1007/BF01487619.

DOI:10.1007/BF01487619
PMID:6350696
Abstract

Twenty patients with cancer previously unresponsive to antiemetic treatment of chemotherapy-induced nausea and vomiting were treated with the new tetrahydrocannabinoid Levonantradol. 15 patients experienced substantial relief and 10 of them preferred the drug for further courses. These observations suggest that Levonantradol can be beneficial to patients refractory to conventional antiemetic therapy.

摘要

20例既往对化疗引起的恶心和呕吐的止吐治疗无反应的癌症患者接受了新型四氢大麻酚左南曲朵治疗。15例患者症状得到显著缓解,其中10例患者更倾向于在后续疗程中继续使用该药物。这些观察结果表明,左南曲朵对传统止吐治疗无效的患者可能有益。

相似文献

1
Levonantradol for the treatment of chemotherapy-induced nausea and vomiting.左诺曲朵用于治疗化疗引起的恶心和呕吐。
Klin Wochenschr. 1983 Jul 15;61(14):719-21. doi: 10.1007/BF01487619.
2
Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting.
Cancer Treat Rep. 1985 Jan;69(1):109-12.
3
Levonantradol: a synthetic cannabinoid in the treatment of severe chemotherapy-induced nausea and vomiting resistant to conventional anti-emetic therapy.
Clin Oncol. 1983 Jun;9(2):143-6.
4
Levonantradol for chemotherapy-induced emesis: phase I-II oral administration.左那曲朵用于化疗引起的呕吐:I-II期口服给药。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):51S-56S. doi: 10.1002/j.1552-4604.1981.tb02573.x.
5
Levonantradol, a new antiemetic with a high rate of side-effects for the prevention of nausea and vomiting in patients receiving cancer chemotherapy.左诺曲朵,一种新型止吐药,用于预防接受癌症化疗患者的恶心和呕吐,但副作用发生率较高。
Cancer Chemother Pharmacol. 1982;9(1):61-4. doi: 10.1007/BF00296765.
6
Clinical experience with levonantradol hydrochloride in the prevention of cancer chemotherapy-induced nausea and vomiting.盐酸左南曲朵预防癌症化疗引起的恶心和呕吐的临床经验。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):86S-89S. doi: 10.1002/j.1552-4604.1981.tb02580.x.
7
Double-blind multiple-dose crossover study of the antiemetic effect of intramuscular levonantradol compared to prochlorperazine.肌肉注射左南曲朵与丙氯拉嗪抗呕吐作用的双盲多剂量交叉研究。
J Clin Pharmacol. 1984 Apr;24(4):155-9. doi: 10.1002/j.1552-4604.1984.tb01824.x.
8
[Treatment of refractory cytostatic agent-induced vomiting with the synthetic cannabinoid levonantradol].[用合成大麻素左南曲朵治疗难治性细胞抑制剂引起的呕吐]
Onkologie. 1982 Apr;5(2):94-6. doi: 10.1159/000214975.
9
[Levonantradol in the treatment of nausea and vomiting caused by cytostatic drugs (author's transl) clinical studies].[左诺曲朵用于治疗细胞毒性药物所致恶心和呕吐(作者译)临床研究]
Dtsch Med Wochenschr. 1982 Aug 20;107(33):1232-4. doi: 10.1055/s-2008-1070107.
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Randomized crossover study of the antiemetic activity of levonantradol and metoclopramide in cancer patients receiving chemotherapy.左纳曲朵与甲氧氯普胺对接受化疗的癌症患者止吐活性的随机交叉研究。
Cancer Chemother Pharmacol. 1984;13(2):123-5. doi: 10.1007/BF00257128.

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Curr Oncol Rep. 2025 Sep;27(9):1080-1096. doi: 10.1007/s11912-025-01695-x. Epub 2025 Aug 1.
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Adverse events associated with the use of cannabis-based products in people living with cancer: a systematic scoping review.癌症患者使用大麻类产品相关的不良事件:一项系统的范围综述。
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Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy.

本文引用的文献

1
Emesis as a critical problem in chemotherapy.呕吐作为化疗中的一个关键问题。
N Engl J Med. 1981 Oct 15;305(16):948-9. doi: 10.1056/NEJM198110153051609.
2
[Levonantradol in the treatment of nausea and vomiting caused by cytostatic drugs (author's transl) clinical studies].[左诺曲朵用于治疗细胞毒性药物所致恶心和呕吐(作者译)临床研究]
Dtsch Med Wochenschr. 1982 Aug 20;107(33):1232-4. doi: 10.1055/s-2008-1070107.
3
[Treatment of refractory cytostatic agent-induced vomiting with the synthetic cannabinoid levonantradol].[用合成大麻素左南曲朵治疗难治性细胞抑制剂引起的呕吐]
大麻素用于接受化疗的成年癌症患者的恶心和呕吐治疗。
Cochrane Database Syst Rev. 2015 Nov 12;2015(11):CD009464. doi: 10.1002/14651858.CD009464.pub2.
4
[New aspects in the antiemetic therapy of cytostatic drug-induced vomiting].
Klin Wochenschr. 1984 May 15;62(10):441-5. doi: 10.1007/BF01726904.
Onkologie. 1982 Apr;5(2):94-6. doi: 10.1159/000214975.
4
The control of chemotherapy-induced emesis.化疗引起的呕吐的控制
Ann Intern Med. 1981 Sep;95(3):352-9. doi: 10.7326/0003-4819-95-3-352.
5
Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis.四氢大麻酚的止吐作用。与安慰剂和氯丙嗪在化疗相关性恶心和呕吐方面的比较。
Arch Intern Med. 1980 Nov;140(11):1431-3. doi: 10.1001/archinte.140.11.1431.
6
Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.Δ⁹-四氢大麻酚对接受癌症化疗患者的止吐作用。
N Engl J Med. 1975 Oct 16;293(16):795-7. doi: 10.1056/NEJM197510162931603.
7
Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.Δ9-四氢大麻酚用于接受癌症化疗患者的止吐作用。与氯丙嗪和安慰剂的比较。
Ann Intern Med. 1979 Dec;91(6):825-30. doi: 10.7326/0003-4819-91-6-825.
8
Suppression of cancer chemotherapy-induced vomiting in the cat by nabilone, a synthetic cannabinoid.合成大麻素纳布隆对猫癌症化疗所致呕吐的抑制作用
Proc Soc Exp Biol Med. 1979 Apr;160(4):437-40. doi: 10.3181/00379727-160-40465.
9
Incidence of nausea and vomiting with cytotoxic chemotherapy: a prospective randomised trial of antiemetics.细胞毒性化疗引起恶心和呕吐的发生率:一项止吐药的前瞻性随机试验。
Br Med J. 1979 May 19;1(6174):1323-4. doi: 10.1136/bmj.1.6174.1323-a.
10
Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.纳布啡酮在接受癌症化疗患者中作为止吐药优于丙氯拉嗪。
N Engl J Med. 1979 Jun 7;300(23):1295-7. doi: 10.1056/NEJM197906073002302.