Sallan S E, Zinberg N E, Frei E
N Engl J Med. 1975 Oct 16;293(16):795-7. doi: 10.1056/NEJM197510162931603.
Anecdotal accounts suggested that smoking marihuana decreases the nausea and vomiting associated with cancer chemotherapeutic agents. Oral delta-9-tetrahydrocannabinol was compared with placebo in a controlled, randomized, "double-blind" experiment. All patients were receiving chemotherapeutic drugs known to cause nausea and vomiting of central origin. Each patient was to serve as his own control to determine whether tetrahydrocannabinol had an antiemetic effect. Twenty-two patients entered the study, 20 of whom were evaluable. For all patients an antiemetic effect was observed in 14 of 20 tetrahydrocannabinol courses and in none of 22 placebo courses. For patients completing the study, response occurred in 12 of 15 courses of tetrahydrocannabinol and in none of 14 courses of placebo (P less than 0.001). No patient vomited while experiencing a subjective "high". Oral tetrahydrocannabinol has antiemetic properties and is significantly better than a placebo in reducting vomiting caused by chemotherapeutic agents.
轶事记录表明，吸食大麻可减轻与癌症化疗药物相关的恶心和呕吐症状。在一项对照、随机、“双盲”实验中，将口服Δ-9-四氢大麻酚与安慰剂进行了比较。所有患者均接受已知会引起中枢性恶心和呕吐的化疗药物。每位患者都作为自身对照，以确定四氢大麻酚是否具有止吐作用。22名患者进入研究，其中20名可进行评估。对于所有患者，在20个四氢大麻酚疗程中有14个观察到止吐效果，而22个安慰剂疗程均未观察到。对于完成研究的患者，15个四氢大麻酚疗程中有12个出现反应，而14个安慰剂疗程均未出现反应（P小于0.001）。没有患者在主观感觉“兴奋”时呕吐。口服四氢大麻酚具有止吐特性，在减轻化疗药物引起的呕吐方面明显优于安慰剂。
