Hardin B D
Toxicology. 1983 Jun;27(2):91-102. doi: 10.1016/0300-483x(83)90014-8.
The glycol ethers are an important and widely used class of solvents. Recent studies have demonstrated that ethylene glycol monomethyl ether (EGME), ethylene glycol dimethyl ether (EGdiME), ethylene glycol monoethyl ether (EGEE), and ethylene glycol monoethyl ether acetate (EGEEA) are teratogenic. Other studies have demonstrated that testicular atrophy or infertility follow treatment of males with EGME, ethylene glycol monomethyl ether acetate (EGMEA), EGEE, EGEEA, diethylene glycol dimethyl ether (diEGdiME), and diethylene glycol monoethyl ether (diEGEE). Experimental data are reviewed and structure-activity relationships are speculated upon.
乙二醇醚是一类重要且广泛使用的溶剂。最近的研究表明，乙二醇单甲醚（EGME）、乙二醇二甲醚（EGdiME）、乙二醇单乙醚（EGEE）和乙二醇单乙醚乙酸酯（EGEEA）具有致畸性。其他研究表明，用EGME、乙二醇单甲醚乙酸酯（EGMEA）、EGEE、EGEEA、二乙二醇二甲醚（diEGdiME）和二乙二醇单乙醚（diEGEE）治疗男性后会出现睾丸萎缩或不育。本文回顾了实验数据并推测了构效关系。
