Poulter L W
Clin Exp Immunol. 1983 Sep;53(3):513-20.
Macrophages and other dendritic non-lymphoid cells have been shown to be functionally capable of presenting antigen to induce lymphocyte responses. These cells can now be studied in situ and distinguished, one from another, within normal tissues and sites of cellular infiltration. Analysis of the microenvironment within which these cells are found can be made with immunohistological methods using monoclonal antibodies (McAbs) and cytochemical techniques. In some cases McAbs are specific for particular types of antigen presenting cell. Using such reagents, evidence is accumulating that these cells may be intimately involved in the pathogenesis of immunoregulatory disorders. What is now required is a more definitive correlation between functional capacity and cell phenotype established with cells isolated from blood, and from normal and pathological tissues. If this is possible the immunopathologist may be able, not only to analyse complex microenvironments but also directly determine the interactions and mechanisms at play within the diseased tissues.
巨噬细胞和其他树突状非淋巴细胞已被证明在功能上能够呈递抗原以诱导淋巴细胞反应。现在可以在原位研究这些细胞，并在正常组织和细胞浸润部位将它们彼此区分开来。可以使用单克隆抗体（McAbs）和细胞化学技术，通过免疫组织学方法分析发现这些细胞的微环境。在某些情况下，单克隆抗体对特定类型的抗原呈递细胞具有特异性。使用这些试剂，越来越多的证据表明这些细胞可能与免疫调节紊乱的发病机制密切相关。现在需要的是从血液、正常组织和病理组织中分离出的细胞所确定的功能能力与细胞表型之间更明确的相关性。如果这是可能的，免疫病理学家不仅能够分析复杂的微环境，还能够直接确定患病组织中起作用的相互作用和机制。
