Bulmer J N, Johnson P M
Clin Exp Immunol. 1984 Aug;57(2):393-403.
Fetal and maternal macrophage populations in human utero-placental tissues at different stages of gestation have been studied using immunohistological and histochemical techniques. A large population of macrophages has been identified within maternal decidualized endometrium in both term and first trimester tissues, although lymphoid cells also constitute a major component of the bone marrow derived cells in the decidua of early pregnancy. In contrast, fetal macrophages have been shown to contribute nearly all of the substantial bone marrow derived cell population within placental chorionic villous mesenchyme and within the mesenchyme of the term amniochorion. Apart from a small population of stellate intensely HLA-DR positive cells in term placental villous stroma, these extra-embryonic fetal macrophages could be shown consistently to express both the leu-M3 tissue macrophage antigen and lysosomal enzyme activities. It is suggested that the major HLA-DR positive cell population of fetal amniochorion comprises 'classical' macrophages rather than dendritic type cells. These various macrophage populations may perform vital phagocytic and degradative functions within utero-placental tissues and amniochorion.
利用免疫组织学和组织化学技术，对不同妊娠阶段人子宫胎盘组织中的胎儿和母体巨噬细胞群体进行了研究。在足月和孕早期组织的母体蜕膜化子宫内膜中均鉴定出大量巨噬细胞，尽管淋巴细胞也是早孕蜕膜中骨髓来源细胞的主要成分。相比之下，已证明胎儿巨噬细胞几乎构成了胎盘绒毛膜间质和足月羊膜绒毛膜间质中大量骨髓来源细胞群体的全部。除了足月胎盘绒毛基质中有一小部分呈强HLA - DR阳性的星状细胞外，这些胚外胎儿巨噬细胞始终能同时表达leu - M3组织巨噬细胞抗原和溶酶体酶活性。有人提出，胎儿羊膜绒毛膜中主要的HLA - DR阳性细胞群体由“经典”巨噬细胞而非树突状细胞组成。这些不同的巨噬细胞群体可能在子宫胎盘组织和羊膜绒毛膜内发挥重要的吞噬和降解功能。
