Lechler R I, Batchelor J R
J Exp Med. 1982 Jan 1;155(1):31-41. doi: 10.1084/jem.155.1.31.
The immunogenicity of long-surviving, enhanced (AS X AUG)F1 renal allografts retransplanted into secondary AS recipients was restored by the injection of small numbers of donor strain dendritic cells derived from afferent lymph. Whereas 1 X 10(4) to 5 X 10(4) dendritic cells were able to trigger an acute rejection response, neither the passenger volume of donor strain blood nor 5 X 10(6) T or B lymphocytes were able to do so, thereby demonstrating more than a 100-fold difference in immunogenic potency. It is concluded that intrarenal dendritic cells provide the major immunogenic stimulus of a kidney allograft. These results suggest that the antigenic strength of major histocompatibility complex-incompatible tissue correlates with the content of donor strain dendritic cells. They also provide further evidence that antigens of the major histocompatibility complex behave like conventional antigens unless they are on the surface of allogeneic dendritic cells.
将长期存活、增强型（AS X AUG）F1肾同种异体移植物再次移植到二级AS受体中，通过注射少量源自传入淋巴的供体品系树突状细胞，其免疫原性得以恢复。虽然1×10⁴至5×10⁴个树突状细胞能够引发急性排斥反应，但供体品系血液的过客量以及5×10⁶个T或B淋巴细胞均无法做到，从而表明免疫原性效力存在超过100倍的差异。得出的结论是，肾内树突状细胞提供了肾同种异体移植物的主要免疫原性刺激。这些结果表明，主要组织相容性复合体不相容组织的抗原强度与供体品系树突状细胞的含量相关。它们还提供了进一步的证据，即主要组织相容性复合体的抗原表现得像传统抗原，除非它们位于同种异体树突状细胞的表面。
