苯乙醇胺N-甲基转移酶抑制剂与肾上腺素生物合成：新药的一个潜在来源。 - Suppr

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: a potential source of new drugs.

作者信息

Bondinell W E, Chapin F W, Frazee J S, Girard G R, Holden K G, Kaiser C, Maryanoff C, Perchonock C D, Gessner G W, Hieble J P

出版信息

Drug Metab Rev. 1983;14(4):709-21. doi: 10.3109/03602538308991406.

DOI:10.3109/03602538308991406

PMID:6352222

Abstract

摘要

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Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: a potential source of new drugs.苯乙醇胺N-甲基转移酶抑制剂与肾上腺素生物合成：新药的一个潜在来源。

Drug Metab Rev. 1983;14(4):709-21. doi: 10.3109/03602538308991406.

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines.苯乙醇胺N-甲基转移酶和肾上腺素生物合成的抑制剂。1. 氯取代的1,2,3,4-四氢异喹啉。

J Med Chem. 1980 May;23(5):506-11. doi: 10.1021/jm00179a007.

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 3. Bis[tetrahydroisoquinoline]s.苯乙醇胺N-甲基转移酶和肾上腺素生物合成的抑制剂。3. 双[四氢异喹啉]类化合物

J Med Chem. 1981 Jun;24(6):756-9. doi: 10.1021/jm00138a023.

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 2. 1,2,3,4-Tetrahydroisoquinoline-7-sulfonanilides.苯乙醇胺N-甲基转移酶和肾上腺素生物合成的抑制剂。2. 1,2,3,4-四氢异喹啉-7-磺酰苯胺类化合物。

J Med Chem. 1980 Aug;23(8):837-40. doi: 10.1021/jm00182a005.

Epinephrine synthesis in the PC12 pheochromocytoma cell line.

Eur J Pharmacol. 1986 Aug 7;127(1-2):139-42. doi: 10.1016/0014-2999(86)90216-5.

Effects of phenylethanolamine N-methyltransferase inhibitors on rat brain catecholamine levels and body temperature.

Res Commun Chem Pathol Pharmacol. 1982 Sep;37(3):445-52.

Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.1,2,3,4-四氢异喹啉3-取代类似物作为苯乙醇胺N-甲基转移酶抑制剂的合成与评价

J Med Chem. 1988 Apr;31(4):824-30. doi: 10.1021/jm00399a024.

The long term effects of an inhibitor of phenylethanolamine N-methyltransferase upon adrenal epinephrine biosynthesis.苯乙醇胺N-甲基转移酶抑制剂对肾上腺肾上腺素生物合成的长期影响。

Naunyn Schmiedebergs Arch Pharmacol. 1976 Nov;295(2):127-33. doi: 10.1007/BF00499444.

Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure.苯乙醇胺 - N - 甲基转移酶抑制剂。2. 苯乙醇胺的非芳香类似物、7,8 - 二氯 - 1,2,3,4 - 四氢异喹啉（SKF - 64139）和2,3 - 二氯 - α - 甲基苄胺的比较：对大鼠脑和肾上腺儿茶酚胺含量及血压的影响。

J Pharmacol Exp Ther. 1982 Nov;223(2):382-7.

Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase.

Prog Neuropsychopharmacol. 1980;4(1):101-5. doi: 10.1016/0364-7722(80)90066-1.

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Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation.迷走神经刺激诱导的神经免疫回路对急性肺部炎症的抑制作用。

Sci Adv. 2025 Jun 6;11(23):eadw7080. doi: 10.1126/sciadv.adw7080. Epub 2025 Jun 4.

Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation.迷走神经刺激诱导的神经免疫回路对急性肺部炎症的抑制作用。

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Molecular pathways underlying sympathetic autonomic overshooting leading to fear and traumatic memories: looking for alternative therapeutic options for post-traumatic stress disorder.导致恐惧和创伤性记忆的交感自主神经亢进的分子通路：寻找创伤后应激障碍的替代治疗选择。

Front Mol Neurosci. 2024 Jan 8;16:1332348. doi: 10.3389/fnmol.2023.1332348. eCollection 2023.

Epinephrine increases contextual learning through activation of peripheral β2-adrenoceptors.肾上腺素通过激活外周β2-肾上腺素能受体增强情境学习。

Psychopharmacology (Berl). 2016 Jun;233(11):2099-2108. doi: 10.1007/s00213-016-4254-5. Epub 2016 Mar 2.

Kinetic and pH studies on human phenylethanolamine N-methyltransferase.人苯乙醇胺 N-甲基转移酶的动力学和 pH 值研究。

Arch Biochem Biophys. 2013 Nov 1;539(1):1-8. doi: 10.1016/j.abb.2013.08.019. Epub 2013 Sep 7.

Polymorphisms and disease: hotspots of inactivation in methyltransferases.多态性与疾病：甲基转移酶失活的热点。

Trends Biochem Sci. 2010 Oct;35(10):531-8. doi: 10.1016/j.tibs.2010.03.007. Epub 2010 Apr 9.

Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay.利用酶偶联的转甲基化测定法鉴定恶性疟原虫磷酸乙醇胺甲基转移酶的抑制剂。

BMC Biochem. 2010 Jan 19;11:4. doi: 10.1186/1471-2091-11-4.

The reaction mechanism of phenylethanolamine N-methyltransferase: a density functional theory study.苯乙醇胺N-甲基转移酶的反应机制：一项密度泛函理论研究

Biochim Biophys Acta. 2009 Dec;1794(12):1831-7. doi: 10.1016/j.bbapap.2009.08.022. Epub 2009 Sep 3.

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Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: a potential source of new drugs.

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