Westaby D, Macdougall B R, Melia W, Theodossi A, Williams R
Hepatology. 1983 Sep-Oct;3(5):681-4. doi: 10.1002/hep.1840030509.
In a study designed to compare the efficacy and safety of two techniques of injection sclerotherapy, 40 patients (30 with cirrhosis and 10 with portal vein block) were randomly allocated to the sheath or free-hand technique. Although the former was associated with significantly less bleeding within the first 24 hr of injection (p less than 0.05) but more postinjection pain (p less than 0.05) and esophageal stricture, there was a trend toward earlier obliteration of varices. This was most marked over the first three courses of injection, and although frequency of rebleeding was not significantly less, none of the 11 episodes in the sheath group were fatal, compared to 5 of 15 bleeds in those injected by the free-hand technique (p less than 0.05).
在一项旨在比较两种注射硬化疗法技术的疗效和安全性的研究中，40例患者（30例肝硬化患者和10例门静脉阻塞患者）被随机分配接受套管技术或徒手技术。尽管前者在注射后的头24小时内出血明显较少（p<0.05），但注射后疼痛更明显（p<0.05）且食管狭窄发生率更高，但静脉曲张闭塞有提前的趋势。这在最初三个注射疗程中最为明显，尽管再出血频率没有显著降低，但套管组的11次出血事件均无致命情况，而徒手技术注射的患者中15次出血中有5次致命（p<0.05）。
