Prinsloo J G, Delport S D, Moncrieff J, Paton A M
J Antimicrob Chemother. 1983 Jul;12 Suppl A:361-4. doi: 10.1093/jac/12.suppl_a.361.
Fifty neonates and infants with suspected or proven bacterial infection were given 30 mg/kg of ceftazidime as a single intravenous dose to investigate the pharmacokinetics of ceftazidime. The mean serum half-lives for babies aged less than 2 months was 4.18 +/- 1.60 h and for those aged 2 to 12 months 2.00 +/- 0.64 h. Dose bands of 25 to 50 mg/kg/day for those less than two months and 50-100 mg/kg/day for those aged 2 to 12 months are recommended for the treatment of suitable bacterial infections.
五十名疑似或确诊为细菌感染的新生儿和婴儿接受了30毫克/千克的头孢他啶单次静脉注射，以研究头孢他啶的药代动力学。小于2个月的婴儿血清平均半衰期为4.18±1.60小时，2至12个月的婴儿为2.00±0.64小时。对于小于2个月的婴儿，建议使用25至50毫克/千克/天的剂量范围，对于2至12个月的婴儿，建议使用50至100毫克/千克/天的剂量范围来治疗合适的细菌感染。
