鼠伤寒沙门氏菌中一个relA依赖性饥饿诱导位点（sin）的鉴定与特性分析。
Identification and characterization of a relA-dependent starvation-inducible locus (sin) in Salmonella typhimurium.
作者信息
Foster J W
出版信息
J Bacteriol. 1983 Oct;156(1):424-8. doi: 10.1128/jb.156.1.424-428.1983.
Abstract
By use of Mu cts d1(Ap lac) phage, a strain of Salmonella typhimurium was isolated containing a Mu d insertion in a locus (sinA) which is induced during nicotinate, thiamine, purine, amino acid, phosphate, and carbon starvation conditions. Depending on the starvation condition, a 2- to 10-fold increase in beta-galactosidase activity was demonstrated. The sinA locus, which mapped at 32 U, became induced after a decline in growth rate due to starvation. The introduction of relA into the sinA-lac strain prevented induction by nicotinate starvation and partially prevented induction by phosphate starvation. The data suggest that sinA responds to changes in growth rate due to various nutrient starvation conditions and probably responds in part to changes in guanosine tetraphosphate levels.
摘要
利用Mu cts d1(Ap lac)噬菌体，分离出一株鼠伤寒沙门氏菌，该菌株在一个基因座（sinA）中有一个Mu d插入，该基因座在烟酸、硫胺素、嘌呤、氨基酸、磷酸盐和碳饥饿条件下被诱导。根据饥饿条件，β-半乳糖苷酶活性提高了2至10倍。位于32 U处的sinA基因座在因饥饿导致生长速率下降后被诱导。将relA导入sinA-lac菌株可防止烟酸饥饿诱导，并部分防止磷酸盐饥饿诱导。数据表明，sinA对各种营养饥饿条件下生长速率的变化作出反应，并且可能部分地对四磷酸鸟苷水平的变化作出反应。
相似文献
1
Identification and characterization of a relA-dependent starvation-inducible locus (sin) in Salmonella typhimurium.鼠伤寒沙门氏菌中一个relA依赖性饥饿诱导位点（sin）的鉴定与特性分析。
J Bacteriol. 1983 Oct;156(1):424-8. doi: 10.1128/jb.156.1.424-428.1983.
2
Identification and characterization of starvation-regulated genetic loci in Salmonella typhimurium by using Mu d-directed lacZ operon fusions.利用 Mud 介导的 lacZ 操纵子融合技术鉴定和表征鼠伤寒沙门氏菌中饥饿调节的基因座。
J Bacteriol. 1988 Jan;170(1):345-51. doi: 10.1128/jb.170.1.345-351.1988.
3
The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locus.鼠伤寒沙门氏菌的中/长链脂肪酰辅酶A脱氢酶（fadF）基因是一个1期饥饿应激反应（SSR）位点。
Microbiology (Reading). 1999 Jan;145 ( Pt 1):15-31. doi: 10.1099/13500872-145-1-15.
4
Correlation between histidine operon expression and guanosine 5'-diphosphate-3'-diphosphate levels during amino acid downshift in stringent and relaxed strains of Salmonella typhimurium.鼠伤寒沙门氏菌严谨型和松弛型菌株在氨基酸降档期间组氨酸操纵子表达与鸟苷 5'-二磷酸-3'-二磷酸水平之间的相关性
J Bacteriol. 1989 Feb;171(2):737-43. doi: 10.1128/jb.171.2.737-743.1989.
5
Relationship between guanosine tetraphosphate and accuracy of translation in Salmonella typhimurium.鼠伤寒沙门氏菌中四磷酸鸟苷与翻译准确性之间的关系。
Biochemistry. 1989 Feb 21;28(4):1814-9. doi: 10.1021/bi00430a058.
6
Phosphate starvation regulon of Salmonella typhimurium.鼠伤寒沙门氏菌的磷酸盐饥饿调节子
J Bacteriol. 1986 May;166(2):666-9. doi: 10.1128/jb.166.2.666-669.1986.
7
Starvation-inducible loci of Salmonella typhimurium: regulation and roles in starvation-survival.鼠伤寒沙门氏菌的饥饿诱导基因座：饥饿存活中的调控及作用
Mol Microbiol. 1992 Jun;6(11):1467-76. doi: 10.1111/j.1365-2958.1992.tb00867.x.
8
Bacteriophage P22 as a vector for Mu mutagenesis in Salmonella typhimurium: isolation of nad-lac and pnc-lac gene fusions.噬菌体P22作为鼠伤寒沙门氏菌中Mu诱变的载体：nad-lac和pnc-lac基因融合体的分离
J Bacteriol. 1982 Nov;152(2):959-62. doi: 10.1128/jb.152.2.959-962.1982.
9
Mutations that render the promoter of the histidine operon of Salmonella typhimurium insensitive to nutrient-rich medium repression and amino acid downshift.使鼠伤寒沙门氏菌组氨酸操纵子的启动子对营养丰富培养基的抑制和氨基酸降调不敏感的突变。
J Bacteriol. 1997 Aug;179(16):5211-7. doi: 10.1128/jb.179.16.5211-5217.1997.
10
apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium.apbA，一个参与鼠伤寒沙门氏菌硫胺素生物合成的新基因座。
J Bacteriol. 1994 Aug;176(16):4858-64. doi: 10.1128/jb.176.16.4858-4864.1994.
引用本文的文献
1
Stringent control during carbon starvation of marine Vibrio sp. strain S14: molecular cloning, nucleotide sequence, and deletion of the relA gene.海洋弧菌属菌株S14在碳饥饿期间的严格控制：relA基因的分子克隆、核苷酸序列及缺失
J Bacteriol. 1994 Oct;176(19):5949-57. doi: 10.1128/jb.176.19.5949-5957.1994.
2
Global control in Salmonella typhimurium: two-dimensional electrophoretic analysis of starvation-, anaerobiosis-, and heat shock-inducible proteins.鼠伤寒沙门氏菌中的全局调控：饥饿、厌氧和热休克诱导蛋白的二维电泳分析
J Bacteriol. 1986 Oct;168(1):420-4. doi: 10.1128/jb.168.1.420-424.1986.
3
Identification and characterization of starvation-regulated genetic loci in Salmonella typhimurium by using Mu d-directed lacZ operon fusions.利用 Mud 介导的 lacZ 操纵子融合技术鉴定和表征鼠伤寒沙门氏菌中饥饿调节的基因座。
J Bacteriol. 1988 Jan;170(1):345-51. doi: 10.1128/jb.170.1.345-351.1988.
4
Linkage map of Salmonella typhimurium, edition VII.鼠伤寒沙门氏菌连锁图谱，第七版。
Microbiol Rev. 1988 Dec;52(4):485-532. doi: 10.1128/mr.52.4.485-532.1988.
5
Phosphate starvation regulon of Salmonella typhimurium.鼠伤寒沙门氏菌的磷酸盐饥饿调节子
J Bacteriol. 1986 May;166(2):666-9. doi: 10.1128/jb.166.2.666-669.1986.
本文引用的文献
1
Positive involvement of ppGpp in derepression of the nif operon in Klebsiella pneumoniae.ppGpp在肺炎克雷伯菌中对固氮酶操纵子去阻遏的正向作用。
Mol Gen Genet. 1982;185(2):198-204. doi: 10.1007/BF00330786.
2
Genetic control of heat-shock protein synthesis and its bearing on growth and thermal resistance in Escherichia coli K-12.大肠杆菌K-12中热休克蛋白合成的遗传控制及其与生长和热抗性的关系。
Proc Natl Acad Sci U S A. 1982 Feb;79(3):860-4. doi: 10.1073/pnas.79.3.860.
3
Phosphate-controlled gene expression in Escherichia coli K12 using Mudl-directed lacZ fusions.利用Mudl定向的lacZ融合技术研究大肠杆菌K12中磷酸盐控制的基因表达。
J Mol Biol. 1982 Jul 5;158(3):347-63. doi: 10.1016/0022-2836(82)90202-9.
4
Bacteriophage P22 as a vector for Mu mutagenesis in Salmonella typhimurium: isolation of nad-lac and pnc-lac gene fusions.噬菌体P22作为鼠伤寒沙门氏菌中Mu诱变的载体：nad-lac和pnc-lac基因融合体的分离
J Bacteriol. 1982 Nov;152(2):959-62. doi: 10.1128/jb.152.2.959-962.1982.
5
Proteins induced by aerobiosis in Escherichia coli.大肠杆菌需氧培养诱导产生的蛋白质。
J Bacteriol. 1983 Apr;154(1):344-50. doi: 10.1128/jb.154.1.344-350.1983.
6
Proteins induced by anaerobiosis in Escherichia coli.大肠杆菌中厌氧诱导产生的蛋白质。
J Bacteriol. 1983 Apr;154(1):336-43. doi: 10.1128/jb.154.1.336-343.1983.
7
Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography.通过二维薄层色谱法对细胞核苷酸进行完整分析。
J Biol Chem. 1982 Aug 25;257(16):9759-69.
8
ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency.ZTP（5-氨基-4-咪唑甲酰胺核糖核苷5'-三磷酸）：一种针对10-甲酰四氢叶酸缺乏症的潜在警报素。
Cell. 1982 Jul;29(3):929-37. doi: 10.1016/0092-8674(82)90455-x.
9
Pyridine nucleotide cycle of Salmonella typhimurium: in vitro demonstration of nicotinamide adenine dinucleotide glycohydrolase, nicotinamide mononucleotide glycohydrolase, and nicotinamide adenine dinucleotide pyrophosphatase activities.鼠伤寒沙门氏菌的吡啶核苷酸循环：烟酰胺腺嘌呤二核苷酸糖水解酶、烟酰胺单核苷酸糖水解酶和烟酰胺腺嘌呤二核苷酸焦磷酸酶活性的体外证明
J Bacteriol. 1981 Feb;145(2):1002-9. doi: 10.1128/jb.145.2.1002-1009.1981.
10
Culture medium for enterobacteria.用于肠道细菌的培养基。
J Bacteriol. 1974 Sep;119(3):736-47. doi: 10.1128/jb.119.3.736-747.1974.
Zotero 插件