Fukumori T, Tani E, Maeda Y, Sukenaga A
J Neurosurg. 1983 Nov;59(5):829-34. doi: 10.3171/jns.1983.59.5.0829.
Isolated canine basilar artery contracted by prostaglandin E2, hemoglobin, or serum was relaxed in a dose-dependent manner by the addition of 10(-8)M to 10(-6)M prostacyclin (PGI2), and was scarcely relaxed by 10(-9)M PGI2. In other studies, intravenous administration of PGI2 (25 or 75 ng/kg/min), indomethacin (4 mg/kg), or indomethacin (4 mg/kg) plus PGI2 (25 ng/kg/min) failed to reverse angiographic delayed vasospasm produced in vivo in the canine basilar artery by an intracisternal injection of blood. In addition, no significant increase occurred in mean values of regional cerebral blood flow (rCBF) with any treatments, and mean rCBF difference in dogs treated by PGI2 infusion at 25 ng/kg/min was 2.5 +/- 1.2 ml/100 gm/min and only significantly increased (p less than 0.01). Mean arterial blood pressure was significantly reduced by PGI2 infusion at 25 (p less than 0.05) or 75 ng/kg/min (p less than 0.005).
由前列腺素E2、血红蛋白或血清收缩的离体犬基底动脉，通过添加10(-8)M至10(-6)M的前列环素（PGI2）以剂量依赖方式舒张，而10(-9)M的PGI2几乎不能使其舒张。在其他研究中，静脉注射PGI2（25或75 ng/kg/分钟）、吲哚美辛（4 mg/kg）或吲哚美辛（4 mg/kg）加PGI2（25 ng/kg/分钟）未能逆转通过脑池内注射血液在犬基底动脉体内产生的血管造影延迟性血管痉挛。此外，任何治疗均未使局部脑血流量（rCBF）的平均值显著增加，以25 ng/kg/分钟的速度输注PGI2治疗的犬的平均rCBF差异为2.5 +/- 1.2 ml/100 gm/分钟，且仅显著增加（p小于0.01）。以25（p小于0.05）或75 ng/kg/分钟（p小于0.005）的速度输注PGI2可使平均动脉血压显著降低。
