Quintana L, Konda R, Ishibashi Y, Okada H, Suzuki J
No Shinkei Geka. 1982 Oct;10(10):1049-52.
Prostacyclin(PGI2), a strong vasodilator of cerebral vessels and a potent inhibitor of platelet aggregation, was infused intravenously in 7 cats after induction of prolonged vasospasm by hourly application of oxyhemoglobin solution into the subarachnoid space around the basilar artery. PGI2, at a concentration of 50 ng/kg/min, was effective in releasing the vasospasm in the 7 cats. On the other hand, PGI2 did not produce significant hypotension. This report will discuss our results and the probable mechanism of action of PGI2 in cerebral vasospasm.
前列环素（PGI2）是一种强力脑血管扩张剂和血小板聚集强效抑制剂。在通过每小时向基底动脉周围蛛网膜下腔注入氧合血红蛋白溶液诱导7只猫发生长时间血管痉挛后，对其进行了前列环素的静脉输注。浓度为50纳克/千克/分钟的前列环素可有效缓解这7只猫的血管痉挛。另一方面，前列环素并未引起明显的低血压。本报告将讨论我们的研究结果以及前列环素在脑血管痉挛中可能的作用机制。
