Chesta J, Debnam E S, Srai S K, Epstein O
Department of Medicine, Free Hospital School of Medicine, London.
Gut. 1990 Jun;31(6):660-2. doi: 10.1136/gut.31.6.660.
Disturbances of gastrointestinal motility are a common feature of diabetes mellitus and are usually ascribed to autonomic neuropathy. In order to assess the role of other factors on changes in motility in diabetes we have studied the stomach to caecum transit time (SCTT) during the progression of streptozotocin induced diabetes in the rat. Rats were used one, two, four, and eight weeks after a single injection of streptozotocin and age matched animals were used as controls. In further experiments non-diabetic rats received a bolus injection of pancreatic glucagon (50 or 75 micrograms intraperitoneally) or its diluent. SCTT was estimated using the non-invasive hydrogen excretion method. SCTT was unaffected by the age of the animal (mean (SEM) value: 101 (5) min), but was significantly delayed at one week (139 (11) min, p less than 0.01), two weeks (163 (16) min, p less than 0.01), four weeks (148 (9) min, p less than 0.01), and eight weeks (171 (13) min, p less than 0.01) after streptozotocin. SCTT was also slower during hyperglucagonaemia (control 96 (6) min; glucagon treated 50 micrograms: 120 (7) min, p less than 0.05 and 75 micrograms: 127 (8), p less than 0.05). Since autonomic neuropathy is not a recognised feature of the initial stages of diabetes hyperglucagonaemia may be responsible, at least in part, for diabetes induced changes in gastrointestinal motility.
胃肠动力紊乱是糖尿病的常见特征，通常归因于自主神经病变。为了评估其他因素在糖尿病患者动力变化中的作用，我们研究了链脲佐菌素诱导的大鼠糖尿病进展过程中胃至盲肠的转运时间（SCTT）。在单次注射链脲佐菌素后的1周、2周、4周和8周使用大鼠，并将年龄匹配的动物作为对照。在进一步的实验中，非糖尿病大鼠接受大剂量腹腔注射胰高血糖素（50或75微克）或其稀释剂。使用非侵入性氢排泄法估计SCTT。SCTT不受动物年龄的影响（平均值（标准误）：101（5）分钟），但在链脲佐菌素注射后1周（139（11）分钟，p<0.01）、2周（163（16）分钟，p<0.01）、4周（148（9）分钟，p<0.01）和8周（171（13）分钟，p<0.01）时显著延迟。高胰高血糖素血症期间SCTT也较慢（对照96（6）分钟；50微克胰高血糖素治疗：120（7）分钟，p<0.05；75微克：127（8），p<0.05）。由于自主神经病变不是糖尿病初始阶段的公认特征，高胰高血糖素血症可能至少部分导致糖尿病引起的胃肠动力变化。
