Curtis J J, Luke R G, Dustan H P, Kashgarian M, Whelchel J D, Jones P, Diethelm A G
N Engl J Med. 1983 Oct 27;309(17):1009-15. doi: 10.1056/NEJM198310273091702.
Six patients in whom "essential hypertension" led to nephrosclerosis and kidney failure received kidney transplants from normotensive donors. After an average follow-up of 4.5 years, all were normotensive and had evidence of reversal of hypertensive damage to the heart and retinal vessels. These six patients, all of whom were black, and six control subjects matched for age, sex, and race were admitted to the General Clinical Research Center for 11 days for observation of their blood pressure and their responses to salt deprivation and salt loading. Mean arterial pressure (+/- S.E.M.) among the patients who had previously had essential hypertension was similar to that of the normal controls (92 +/- 1.9 vs. 94 +/- 3.9; P not significant), and both groups had similar responses to salt deprivation and salt loading. Thus, essential hypertension in human beings is shown to be similar to the hypertension seen in spontaneously hypertensive rats in that both can be corrected by transplantation of a kidney from a normotensive donor. This observation supports the concept of the primary of the kidney in causing essential hypertension.
6例因“原发性高血压”导致肾硬化和肾衰竭的患者接受了血压正常供体的肾移植。平均随访4.5年后，所有患者血压均正常，且有证据表明心脏和视网膜血管的高血压损害有所逆转。这6例患者均为黑人，另外6名年龄、性别和种族匹配的对照受试者被收入综合临床研究中心观察11天，以监测他们的血压以及对限盐和高盐饮食的反应。既往有原发性高血压的患者的平均动脉压（±标准误）与正常对照组相似（92±1.9对94±3.9；P值无统计学意义），两组对限盐和高盐饮食的反应也相似。因此，人类原发性高血压与自发性高血压大鼠的高血压相似，两者均可通过移植血压正常供体的肾脏得到纠正。这一观察结果支持了肾脏在原发性高血压发病中起主要作用的观点。
