Immonen I, Siimes A, Stenman U H, Kärkkäinen J, Fyhrquist F
Scand J Clin Lab Invest. 1983 Feb;43(1):61-5.
Relationship between concentrations of serum oestrogens, plasma renin substrate and plasma renin activity were studied in six women throughout pregnancy. There was a significant positive correlation between serum oestradiol-17 beta and plasma renin substrate concentrations (r=0.60). Serum oestriol concentrations also correlated significantly with plasma renin substrate concentrations (r = 0.68). Correlation coefficients calculated separately for each subject throughout pregnancy were higher than those for the whole group. Also, there was much individual variation in dose-response of serum oestrogens to plasma renin substrate concentrations. There was no significant correlation between serum oestrogens and plasma renin activity. Our results support the view that oestrogens cause the increase in plasma renin substrate concentration during pregnancy, and emphasize the individual variation in response of renin substrate concentration to serum level of oestrogens.
对六名女性在整个孕期的血清雌激素浓度、血浆肾素底物和血浆肾素活性之间的关系进行了研究。血清雌二醇 - 17β与血浆肾素底物浓度之间存在显著正相关（r = 0.60）。血清雌三醇浓度也与血浆肾素底物浓度显著相关（r = 0.68）。在整个孕期为每个受试者单独计算的相关系数高于整个组的相关系数。此外，血清雌激素对血浆肾素底物浓度的剂量反应存在很大的个体差异。血清雌激素与血浆肾素活性之间无显著相关性。我们的结果支持雌激素导致孕期血浆肾素底物浓度升高的观点，并强调肾素底物浓度对血清雌激素水平反应的个体差异。
