Klapdor R, Aban Y, Sepehr H, Scherer K
Rontgenblatter. 1978 Feb;31(2):114-9.
The distribution and biliary excretion of two hepatotropic contrast media, Ioglycamate and Iotroxinate, has been studied in the anaesthetized pig in infusion experiments. The new substance Iotroxinate exceeds the Ioglycamate in two of the investigated parameters: it was excreted faster and reached a higher biliary concentration. The biliary transport maximum, however, was unchanged. On the basis of these experiments the new contrast medium Iotroxinate was tested in men.
在麻醉猪的输注实验中,研究了两种亲肝性造影剂碘甘氨酸盐和碘托酸盐的分布及胆汁排泄情况。新物质碘托酸盐在两个研究参数上超过了碘甘氨酸盐:它排泄得更快,且胆汁浓度更高。然而,胆汁转运最大值没有变化。基于这些实验,对新造影剂碘托酸盐进行了人体试验。