Klapdor R, Valerius H, Zschukke N
Res Exp Med (Berl). 1976 Jul 2;167(3):217-29. doi: 10.1007/BF01851646.
16 experiments were performed in order to investigate the mechanisms of biliary excretion of Ioglycamide in the mini-pig. The results confirm the mechanisms known from other species for this experimental animal. Additionally, however, they demonstrate a significant linear correlation between the spontaneous bile flow and the biliary transport-maximum of Ioglycamide. It is concluded that this correlation is due to the fact that the bile flow as well as the transport-maximum represent independent parameters of the excretory capacity of the liver cells. This conclusion is supported by further experiments that were unable to show an improvement of the biliary transport-maximum of Ioglycamide by stimulation of the bile flow during infusions of bile acids and secretin. These results prove the impossibility to enhance the biliary excretion of Ioglycamide by stimulation of bile flow. This, however, indicates that it is possible to dilute or concentrate the biliary Ioglycamide concentration by induced variations of bile flow, a fact that might become important to improve the efficiency of i.v. cholegraphy.
为了研究碘甘脲在小型猪体内的胆汁排泄机制，进行了16项实验。结果证实了该实验动物与其他物种已知的机制相同。然而，此外，他们还证明了自发性胆汁流量与碘甘脲的胆汁转运最大值之间存在显著的线性相关性。得出的结论是，这种相关性是由于胆汁流量以及转运最大值代表了肝细胞排泄能力的独立参数。进一步的实验支持了这一结论，即在输注胆汁酸和促胰液素期间，刺激胆汁流量并不能提高碘甘脲的胆汁转运最大值。这些结果证明了通过刺激胆汁流量来增强碘甘脲胆汁排泄的可能性不存在。然而，这表明可以通过诱导胆汁流量的变化来稀释或浓缩胆汁中碘甘脲的浓度，这一事实对于提高静脉胆管造影的效率可能很重要。
