Growth of Candida albicans on artificial D-glucose derivatives.

Growth of Candida albicans on artificial D-glucose derivatives (amino-, methyl-, acylglycosides and N-acetyl-D-glucosamine derivatives) was examined with the aim to find new inducers of the mycelial growth form. For representatives of particular groups (alpha-D-glucopyranosylamine, D-glucose and N-acetyl-D-glucosamine) some physiological (growth, doubling time, specific growth rate, oxygen uptake and CO2 production, respiration quotients), biochemical (dry weight yield, protein content, ethanol production), and morphological parameters (length-width quotient, volume, percentage of budding cells) of cultures in different growth phases were determined with regard to the type and concentration of carbon source. The results obtained may be valuable for studies of the structure-utilization relationships of carbohydrate derivatives as well as for the elucidation of yeast-mycelial transition in Candida albicans induced by unphysiological hexoses degradable intracellularly.