[Beta 2 microglobulin in the serum as a parameter for the evaluation of kidney function in pregnant patients with EPH gestosis].

The renal function of 27 pregnant women with EPH-gestosis were determined by measuring the level of proteinuria, the serum concentration of blood-urea-n (BUN), creatinin, beta 2-microglobulin and the creatinin clearance, in comparison with, 39 healthy pregnant women were examined. For statistics the regressions line with the week of gestation and spearman correlation between our parameters (proteinuria, BUN, creatinin, creatinin clearance and gestosis-index) were determined. The level of the proteinuria as well as the concentration of BUN and serum-creatinin are only limited useful to check the degree of a restriction of the renal function in EPH gestosis. Significant correlations were found between beta 2-microglobulin concentration and the serum creatinin concentration as well as the creatinin clearance, but not between beta 2-microglobulin and the gestosis index. Immunologic reactions in EPH-gestosis seem not to have a significant influence on beta 2-microglobulin concentration, but only the restriction of the degree of the glomerular filtration. Therefore beta 2-microglobulin is a useful parameter for renal function.