Bartl W
Z Geburtshilfe Perinatol. 1983 Jul-Aug;187(4):178-82.
The renal function of 27 pregnant women with EPH-gestosis were determined by measuring the level of proteinuria, the serum concentration of blood-urea-n (BUN), creatinin, beta 2-microglobulin and the creatinin clearance, in comparison with, 39 healthy pregnant women were examined. For statistics the regressions line with the week of gestation and spearman correlation between our parameters (proteinuria, BUN, creatinin, creatinin clearance and gestosis-index) were determined. The level of the proteinuria as well as the concentration of BUN and serum-creatinin are only limited useful to check the degree of a restriction of the renal function in EPH gestosis. Significant correlations were found between beta 2-microglobulin concentration and the serum creatinin concentration as well as the creatinin clearance, but not between beta 2-microglobulin and the gestosis index. Immunologic reactions in EPH-gestosis seem not to have a significant influence on beta 2-microglobulin concentration, but only the restriction of the degree of the glomerular filtration. Therefore beta 2-microglobulin is a useful parameter for renal function.
通过测量蛋白尿水平、血尿素氮（BUN）、肌酐、β2-微球蛋白的血清浓度以及肌酐清除率，对27例患有妊娠高血压综合征（EPH-妊娠中毒症）的孕妇的肾功能进行了测定，并与39例健康孕妇进行了比较。为了进行统计学分析，确定了妊娠周数的回归线以及我们的参数（蛋白尿、BUN、肌酐、肌酐清除率和妊娠中毒症指数）之间的斯皮尔曼相关性。蛋白尿水平以及BUN和血清肌酐浓度在检查EPH妊娠中毒症中肾功能受限程度方面仅具有有限的作用。发现β2-微球蛋白浓度与血清肌酐浓度以及肌酐清除率之间存在显著相关性，但β2-微球蛋白与妊娠中毒症指数之间不存在显著相关性。EPH妊娠中毒症中的免疫反应似乎对β2-微球蛋白浓度没有显著影响，而仅对肾小球滤过程度有影响。因此，β2-微球蛋白是评估肾功能的一个有用参数。
