Sighetea E, Leahu S, Bujar H, Roxin T, Guran M, Micu D
Med Interne. 1978 Jan-Mar;16(1):67-72.
Clinical, biological, radiological and radioisotope investigations in 224 patients with Hodgkin's disease revealed a great frequency (100 cases, i.e. 44%) of mediastinal and pleuro-pulmonary involvements, most of them in advanced stages of the disease. The predominant histologic types in these cases were mixed cellularity or nodular sclerosis. Evolution and prognosis were improved by combination chemotherapy in COOP courses; X-ray therapy was associated after drug therapy only if absolutely necessary, on limited areas.
对224例霍奇金病患者进行的临床、生物学、放射学和放射性同位素检查显示，纵隔和胸膜肺部受累的频率很高（100例，即44%），其中大多数处于疾病晚期。这些病例中主要的组织学类型为混合细胞型或结节硬化型。联合化疗（COOP方案）改善了疾病的进展和预后；仅在绝对必要时，对有限区域在药物治疗后联合进行X线治疗。
