Honey N K, Shows T B
Cancer Genet Cytogenet. 1983 Nov;10(3):287-310. doi: 10.1016/0165-4608(83)90058-4.
The tumor phenotype is associated with the rearrangement of genetic information and the altered expression of many gene products. In this review, genes associated with the tumor phenotype have been arranged on the human gene map and indicate the extent to which the tumor phenotype involves the human genome. Nonrandom chromosomal aberrations that are frequently observed in tumors are presented. Altered metabolic demands of the tumor cell are reflected in altered gene expressions of a wide range of enzymes and other proteins, and these changed enzyme patterns are described. The study of oncogenes increasingly suggests that they may be significant in certain cancers, and the assignment of these genes has been tabulated. The biochemical and metabolic changes observed in tumors are complex; studying the patterns and interactions of these changes will aid our genetic understanding of the origins and development of tumors.
肿瘤表型与遗传信息的重排以及许多基因产物表达的改变相关。在本综述中，与肿瘤表型相关的基因已被排列在人类基因图谱上，这表明肿瘤表型涉及人类基因组的程度。文中呈现了肿瘤中经常观察到的非随机染色体畸变。肿瘤细胞代谢需求的改变反映在多种酶和其他蛋白质基因表达的改变上，并且描述了这些变化的酶模式。对癌基因的研究越来越表明它们可能在某些癌症中具有重要意义，并且这些基因的定位已被制成表格。在肿瘤中观察到的生化和代谢变化是复杂的；研究这些变化的模式和相互作用将有助于我们从遗传学角度理解肿瘤的起源和发展。
