Rossouw J E, Labadarios D, Krasner N, Davis M, Williams R
Scand J Gastroenterol. 1978;13(2):133-8. doi: 10.3109/00365527809181738.
Biochemical evidence of thiamine deficiency was found in 58% of patients with chronic liver disease, the incidence being higher in alcoholic than in non-alcoholic patients. Daily supplementation with high doses of thiamine hydrochloride (200 mg/day) for one week restored levels of thiamine pyrophosphate (TPP), the active co-enzyme form of thiamine, to normal in all cases. Such supplementation also stimulated synthesis of the TPP dependent enzyme transketolase. Because of the essential role of TPP as a co-factor in intermediary metabolism, it is concluded that high doses of thiamine should be included in the routine nutritional management of patients with severe chronic liver disease.
在58%的慢性肝病患者中发现了硫胺素缺乏的生化证据，酒精性肝病患者的发生率高于非酒精性肝病患者。每天补充高剂量盐酸硫胺素（200毫克/天），持续一周，可使硫胺素的活性辅酶形式——硫胺素焦磷酸（TPP）水平在所有病例中恢复正常。这种补充还刺激了依赖TPP的转酮醇酶的合成。由于TPP作为中间代谢中的辅助因子发挥着重要作用，因此得出结论，在重度慢性肝病患者的常规营养管理中应包含高剂量的硫胺素。
