水泡性口炎病毒新合成的G蛋白在有丝分裂期间不会转运到细胞表面。
Newly synthesized G protein of vesicular stomatitis virus is not transported to the cell surface during mitosis.
作者信息
Warren G, Featherstone C, Griffiths G, Burke B
出版信息
J Cell Biol. 1983 Nov;97(5 Pt 1):1623-8. doi: 10.1083/jcb.97.5.1623.
Abstract
Indirect immunofluorescence, immunoelectron microscopy, and digestion by protease were used to study intracellular transport of the G protein of vesicular stomatitis virus in mitotic and interphase cells. Quantitation showed that the appearance of G protein on the surface of mitotic cells was inhibited at least 10-fold when compared with that on interphase cells, even though similar amounts of viral protein were being synthesized. This dramatic inhibition, taken together with the simultaneous inhibition of endocytosis (Berlin, R. D., and J. M. Oliver, 1980, J. Cell Biol. 85: 660-671), points to a general cessation of membrane traffic in the mitotic cell.
摘要
采用间接免疫荧光、免疫电子显微镜以及蛋白酶消化法，研究有丝分裂细胞和间期细胞中水泡性口炎病毒G蛋白的细胞内运输。定量分析表明，尽管合成的病毒蛋白量相似，但与间期细胞相比，有丝分裂细胞表面G蛋白的出现受到至少10倍的抑制。这种显著的抑制作用，连同对胞吞作用的同时抑制（Berlin, R. D., and J. M. Oliver, 1980, J. Cell Biol. 85: 660 - 671），表明有丝分裂细胞中膜运输普遍停止。
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