Immunological aspects in Plasmodium falciparum infection.

Patients with P. falciparum infection were shown to have circulating immune complexes in their sera detected by the inhibition of IgG-coated latex agglutination with RF factor and by the EAC rosette inhibition test. Low numbers of T cells and high numbers of B cells which contain immunoglobulins were demonstrated. T-cell depletion may be caused by antibody to T-lymphocytes being present in the sera of these patients.