Wells R A, Pavanand K, Zolyomi S, Permpanich B, MacDermott R P
Clin Exp Immunol. 1979 Feb;35(2):202-9.
Peripheral blood mononuclear cells from forty-nine Thai adults infected with either Plasmodium falciparum or Plasmodium vivax were examined in order to determine the percentage of T, B, and Fc-receptor-bearing cells present. In comparison to healthy controls, both the percentage and concentration of peripheral T cells were decreased in the malaria-infected individuals as assessed by formation of rosettes with sheep red blood cells. The percentage of peripheral B cells was increased but their concentration was unchanged, as assessed by two techniques: the presence of surface immunoglobulin and the presence of a complement receptor. Both the percentage and concentration of lymphocytes bearing Fc receptors were unchanged in infected individuals. Finally, calculation of the changes in 'null' cells (defined either as non-T, non-B lymphocytes or as non-T, non-B, non Fc-receptor-bearing lymphocytes) revealed an increase in the 'null' cell percentage but a decrease in the absolute number of 'null' cells. These data indicate that in adult Thai patients naturally infected with malaria, there is a real loss of circulating T lymphocytes with no real change in B, Fc-receptor-bearing, or 'null' lymphocytes.
对49名感染恶性疟原虫或间日疟原虫的泰国成年人的外周血单个核细胞进行检测，以确定T细胞、B细胞和携带Fc受体细胞的百分比。与健康对照相比，通过与绵羊红细胞形成玫瑰花结评估，疟疾感染个体的外周血T细胞百分比和浓度均降低。外周血B细胞百分比增加但其浓度未变，这是通过两种技术评估得出的：表面免疫球蛋白的存在和补体受体的存在。感染个体中携带Fc受体的淋巴细胞百分比和浓度均未改变。最后，对“裸”细胞（定义为非T、非B淋巴细胞或非T、非B、非携带Fc受体淋巴细胞）变化的计算显示，“裸”细胞百分比增加，但“裸”细胞绝对数量减少。这些数据表明，在自然感染疟疾的成年泰国患者中，循环T淋巴细胞确实减少，而B细胞、携带Fc受体的淋巴细胞或“裸”淋巴细胞没有实际变化。
