利巴韦林气雾剂治疗婴儿呼吸道合胞病毒感染所致细支气管炎

Ribavirin aerosol treatment of bronchiolitis associated with respiratory syncytial virus infection in infants.

作者信息

Taber L H, Knight V, Gilbert B E, McClung H W, Wilson S Z, Norton H J, Thurson J M, Gordon W H, Atmar R L, Schlaudt W R

出版信息

Pediatrics. 1983 Nov;72(5):613-8.

Abstract

In a double-blind study, bronchiolitis associated with respiratory syncytial virus infection in 12 randomly selected patients treated with ribavirin aerosol improved more rapidly than in 14 control patients given saline aerosol (P = .044, Wilcoxon rank sum test, two-tailed). An estimated 10 mg of ribavirin per kilogram of body weight was administered in daily 12-hour treatments over a five-day period. Respiratory syncytial virus disappeared from secretions at about the same rate in treated and control patients. There was no local or systemic intolerance, and there was no evidence of hematologic or other organ toxicity in the ribavirin-treated patients.

摘要

在一项双盲研究中，12名随机选择的接受利巴韦林气雾剂治疗的呼吸道合胞病毒感染所致细支气管炎患者，其病情改善速度比14名接受盐水气雾剂治疗的对照患者更快（P = 0.044，Wilcoxon秩和检验，双侧）。在为期五天的时间里，每天进行12小时的治疗，估计每公斤体重给予10毫克利巴韦林。呼吸道合胞病毒在治疗组和对照组患者分泌物中的消失速度大致相同。未出现局部或全身不耐受情况，且接受利巴韦林治疗的患者没有血液学或其他器官毒性的证据。