van Houte J
Rev Infect Dis. 1983 Sep-Oct;5 Suppl 4:S659-69. doi: 10.1093/clinids/5.supplement_4.s659.
Studies of the adherence of bacteria indigenous to the human mouth have contributed greatly to our understanding of oral bacterial ecology. Bacterial adhesion to teeth and oral epithelial surfaces seems to be indispensable for the formation of dental plaque and for the persistent colonization of mucosal surfaces. The strength of adhesion to various oral surfaces differs widely among oral bacteria and is a major reason for their different intraoral localization. Considerable evidence suggests that the adhesion of different bacteria to the acquired pellicle on teeth or to mucosal surfaces as well as the adhesive processes involved in plaque accumulation entail different, specific interactions that are mediated by receptors on the bacterial cell surface, on the oral surfaces, and on plaque matrix components. Some of these interactions may involve lectin-like binding. Knowledge of the mechanisms by which suspected odontopathogens such as Streptococcus mutans and certain Actinomyces species may adhere to oral surfaces has been discussed. Successful methods for interfering with bacterial adhesion to human oral surfaces have not been developed yet.
对人类口腔中固有细菌黏附情况的研究，极大地促进了我们对口腔细菌生态学的理解。细菌黏附于牙齿和口腔上皮表面，对于牙菌斑的形成以及黏膜表面的持续定植似乎是必不可少的。不同口腔细菌对各种口腔表面的黏附强度差异很大，这是它们在口腔内定位不同的主要原因。大量证据表明，不同细菌对牙齿上获得性薄膜或黏膜表面的黏附以及菌斑积聚过程中涉及的黏附过程，需要不同的特异性相互作用，这些相互作用由细菌细胞表面、口腔表面和菌斑基质成分上的受体介导。其中一些相互作用可能涉及类凝集素结合。已对变形链球菌和某些放线菌属等疑似致龋菌黏附于口腔表面的机制进行了讨论。目前尚未开发出成功干扰细菌黏附于人类口腔表面的方法。
