胃溃疡的短期治疗：硫糖铝与西咪替丁的比较。
Short term treatment of gastric ulcer: a comparison of sucralfate and cimetidine.
作者信息
Hallerbäck B, Anker-Hansen O, Carling L, Glise H, Solhaug J H, Svedberg L E, Wählby L
出版信息
Gut. 1986 Jul;27(7):778-83. doi: 10.1136/gut.27.7.778.
A double blind randomised study was undertaken to compare sucralfate and cimetidine in short term treatment of gastric ulcer. The study included 149 patients with endoscopically confirmed gastric ulcerations. Patients with prepyloric ulcers 2 cm or less from the pyloric ring were not accepted for participation in the trial. Ulcer healing was assessed endoscopically at four week intervals. A total of 134 patients completed the study. The cumulative healing rates after 12 weeks were 98% for sucralfate and 94% for cimetidine treated patients. After four and eight weeks, the healing rates were 61% and 94% for sucralfate and 69% and 94% for the cimetidine-treated group respectively. No statistically significant differences in healing rates were seen. The 95% confidence interval was calculated for the difference between the ulcer healing rates of sucralfate and cimetidine. This interval was found to range between +11% and -2% after 12 weeks of treatment - that is, the healing efficacy of sucralfate was calculated to be at most 11% better or 2% worse than that of cimetidine. No significant differences in symptom relief, side effects or antacid intake were found.
进行了一项双盲随机研究，以比较硫糖铝和西咪替丁在胃溃疡短期治疗中的效果。该研究纳入了149例经内镜确诊为胃溃疡的患者。距幽门环2厘米或更小的幽门管溃疡患者不纳入该试验。每隔4周通过内镜评估溃疡愈合情况。共有134例患者完成了研究。治疗12周后，硫糖铝组和西咪替丁组的累积愈合率分别为98%和94%。4周和8周后，硫糖铝组的愈合率分别为61%和94%，西咪替丁组分别为69%和94%。愈合率未见统计学显著差异。计算了硫糖铝和西咪替丁溃疡愈合率差异的95%置信区间。治疗12周后，该区间在+11%至-2%之间，即硫糖铝的愈合疗效计算结果比西咪替丁最多好11%或差2%。在症状缓解、副作用或抗酸剂摄入量方面未发现显著差异。
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