Nutt A
Scand J Work Environ Health. 1983;9 Suppl 2:49-57.
In the early years, the study of health in the rubber industry was hampered by lack of information in three fields. Epidemiology was just beginning, industrial hygiene had hardly begun, and little or no work had been done on the ways in which rubber chemicals affect the human body. The difficulties this created can clearly be seen in the problems of bladder cancer discovered in the industry in 1949. Since that time epidemiologic studies have become very detailed, more results are available on concentrations of material in factory atmospheres, and the effects of different chemicals on the body are being better understood. This review considers the historical problems of beta-naphthylamine exposure, summarizes the epidemiologic results on the industry to date, and considers the potential problems posed by polycyclic aromatic hydrocarbons and nitrosamines.
在早期，橡胶行业的健康研究因三个领域信息匮乏而受阻。流行病学才刚刚起步，工业卫生几乎尚未开展，关于橡胶化学物质如何影响人体的研究很少或几乎没有。1949年该行业发现的膀胱癌问题清楚地表明了由此产生的困难。从那时起，流行病学研究变得非常详细，工厂空气中物质浓度的更多结果可供使用，不同化学物质对人体的影响也得到了更好的理解。这篇综述考虑了β-萘胺暴露的历史问题，总结了该行业迄今为止的流行病学结果，并考虑了多环芳烃和亚硝胺带来的潜在问题。
