Tandon A, Srivastava A K, Saxena R P, Saxena R K, Saxena K C
Trans R Soc Trop Med Hyg. 1983;77(4):439-41. doi: 10.1016/0035-9203(83)90104-9.
An ELISA was developed using cross-reacting antigens of Litomosoides carinii and Setaria cervi to detect antibodies in filarial patients. The diagnostic potential of the test was investigated in 80 symptomatic cases of filariasis, 40 asymptomatic carriers and 50 normal subjects of an area around Lucknow endemic for Bancroftian filariasis. By the criteria laid down for ELISA positivity for filariasis, 86.2% of the symptomatic cases could be detected by this test. Only four of 40 asymptomatic carriers and one of 50 normal subjects gave a positive ELISA response. Purified antigenic fractions of S. cervi are also promising for detecting asymptomatic carriers.
利用卡氏丝虫和鹿丝状线虫的交叉反应抗原开发了一种酶联免疫吸附测定法（ELISA），用于检测丝虫病患者体内的抗体。在勒克瑙周边班氏丝虫病流行地区，对80例有症状的丝虫病病例、40例无症状携带者和50名正常受试者进行了该检测的诊断潜力研究。根据丝虫病ELISA阳性的判定标准，该检测可检测出86.2%的有症状病例。40例无症状携带者中只有4例、50名正常受试者中只有1例ELISA反应呈阳性。鹿丝状线虫的纯化抗原组分在检测无症状携带者方面也很有前景。
