Reinisch C L, Schlossman S F
J Natl Cancer Inst. 1976 Dec;57(6):1277-81. doi: 10.1093/jnci/57.6.1277.
Inoculation of C57BL/6J mice with allogeneic P815 mastocytoma cells in the presence of simian virus 40 (SV40), a DNA tumor virus, led to an enhanced cytolytic T-cell response to P815 in vivo. Cytotoxic function was also augmented if SV40 was given subsequent to a primary immunization, even when mice were given a suboptimal dose of immunizing cells. Although SV40 increased the cell-mediated immune response to allogeneic cells, it did not enhance the antibody response to the soluble antigen dinitrophenyl bovine gamma-globulin, a helper T-cell-dependent response. Thus it appeared that SV40 had a selective adjuvant effect on lymphocyte subpopulations, since it increased cytotoxicity but not helper T-cell function.
在DNA肿瘤病毒猿猴病毒40（SV40）存在的情况下，用同种异体P815肥大细胞瘤细胞接种C57BL/6J小鼠，可导致体内对P815的细胞溶解性T细胞反应增强。如果在初次免疫后给予SV40，即使给小鼠接种次优剂量的免疫细胞，细胞毒性功能也会增强。尽管SV40增强了对同种异体细胞的细胞介导免疫反应，但它并未增强对可溶性抗原二硝基苯基牛γ球蛋白（一种依赖辅助性T细胞的反应）的抗体反应。因此，似乎SV40对淋巴细胞亚群具有选择性佐剂作用，因为它增加了细胞毒性但未增强辅助性T细胞功能。
