负责对肥大细胞瘤细胞进行细胞介导细胞毒性杀伤的T细胞与辅助细胞效应之间的关系。
The relation between the T cells responsible for cell-mediated cytotoxic killing of mastocytoma cells and the helper-cell effect.
作者信息
Igarashi T, Okada M, Kishimoto S, Yamamura Y
出版信息
Immunology. 1975 Jan;28(1):37-47.
The relationship between T cells involved in cell-mediated immunity and antibody response of C57Bl/6J mice towards DBA/2 mastocytoma cells was investigated. Spleen cells primed with viable mastocytoma cells demonstrated marked cell-mediated cytotoxicity (CMC) in vitro, but antibody response of these cells to a hapten (TNP) conjugated to the allogeneic tumour cells in vitro was suppressed as compared with that of normal spleen cells. In contrast, spleen cells primed with frozen-thawed mastocytoma cells showed no CMC, but antibody response to the hapten in vitro of these cells was enhanced. C57Bl/6J mice primed with frozen-thawed mastocytoma cells produced more cytotoxic antibody than non-primed mice when immunized with viable mastocytoma cells. These results indicate that T cells involved in cell-mediated immunity and those involved in the antibody response to allogeneic mastocytoma cells are distinct.?222
研究了参与细胞介导免疫的T细胞与C57Bl/6J小鼠针对DBA/2肥大细胞瘤细胞的抗体反应之间的关系。用活的肥大细胞瘤细胞致敏的脾细胞在体外表现出明显的细胞介导细胞毒性（CMC），但与正常脾细胞相比，这些细胞对与同种异体肿瘤细胞偶联的半抗原（TNP）的体外抗体反应受到抑制。相反，用冻融的肥大细胞瘤细胞致敏的脾细胞未显示CMC，但这些细胞对体外半抗原的抗体反应增强。用冻融的肥大细胞瘤细胞致敏的C57Bl/6J小鼠在用活的肥大细胞瘤细胞免疫时比未致敏的小鼠产生更多的细胞毒性抗体。这些结果表明，参与细胞介导免疫的T细胞与参与针对同种异体肥大细胞瘤细胞的抗体反应的T细胞是不同的。
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