[免疫发生过程中的细胞间信息传递。IX. 不同组分的免疫核RNA对大鼠淋巴肉瘤细胞中抗噬菌体抗体合成的诱导作用]
[Intercellular information transfer in the process of immunogenesis. IX. The induction of the synthesis of antiphage antibodies in lymphosarcoma cells of rats as affected by different fractions of immune nuclear RNA].
作者信息
Pogodina O N, Sleptsova L A, Aksenovova N N, Fel' V Ia
出版信息
Tsitologiia. 1983 Aug;25(8):953-7.
PMID:6356534
Abstract
Various fractions of the immune nuclear RNA were isolated from spleens of phage T2 immunized rats. The fractions were compared for their ability to induce anti-phage T2 antibody synthesis in transplantable lymphosarcoma cells. The most active proved to be the nuclear sap RNA and its subfraction with sedimentation constant of 10 S. The 4S and 26S subfractions RNA were less stable and in some experiments failed to induce antibody synthesis.
摘要
从经噬菌体T2免疫的大鼠脾脏中分离出免疫核RNA的不同组分。比较了这些组分在可移植性淋巴肉瘤细胞中诱导抗噬菌体T2抗体合成的能力。结果证明，最具活性的是核液RNA及其沉降常数为10S的亚组分。4S和26S亚组分RNA稳定性较差，在某些实验中未能诱导抗体合成。
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