Sener A, Malaisse-Lagae F, Malaisse W J
Acta Diabetol Lat. 1983 Jul-Sep;20(3):205-9. doi: 10.1007/BF02581264.
Insulin release induced by 3-phenylpyruvate in rat pancreatic islets was unaffected by L-norleucine, L-valine, L-alanine and L-asparagine, but potentiated by L-glutamine, glycine and L-serine. The latter two amino acids also enhanced insulin secretion evoked by the combination of 3-phenylpyruvate and L-glutamine. Since 3-phenylpyruvate is known to stimulate insulin release by acting as a transamination partner and facilitating the catabolism of endogenous amino acids, the present findings suggest that the secretory efficiency of such a biochemical sequence depends upon the subcellular location of the transamination reaction and upon the interference of 3-phenylpyruvate with the transport of 2-keto acids into mitochondria.
3-苯丙酮酸诱导大鼠胰岛释放胰岛素不受L-正亮氨酸、L-缬氨酸、L-丙氨酸和L-天冬酰胺的影响，但L-谷氨酰胺、甘氨酸和L-丝氨酸可增强其作用。后两种氨基酸还增强了3-苯丙酮酸和L-谷氨酰胺联合诱导的胰岛素分泌。由于已知3-苯丙酮酸通过作为转氨基反应伙伴并促进内源性氨基酸的分解代谢来刺激胰岛素释放，目前的研究结果表明，这种生化序列的分泌效率取决于转氨基反应的亚细胞定位以及3-苯丙酮酸对2-酮酸进入线粒体转运的干扰。
