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2
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Influence of amino acids upon insulin release evoked by 3-phenylpyruvate.氨基酸对3-苯丙酮酸诱发的胰岛素释放的影响。
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8
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本文引用的文献

1
Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain.苯丙酮酸对大鼠脑内脂肪酸合成相关酶的影响。
Biochem J. 1973 Jun;134(2):545-55. doi: 10.1042/bj1340545.
2
Quantification of cells in islets of Langerhans using DNA determination.利用DNA测定法对胰岛中的细胞进行定量分析。
Acta Diabetol Lat. 1981;18(1):51-7. doi: 10.1007/BF02056106.
3
Changes of function and metabolism of the pancreatic B-cell caused by amino acids and related compounds.氨基酸及相关化合物引起的胰腺β细胞功能和代谢变化。
Horm Metab Res Suppl. 1980;Suppl 10:27-30.
4
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase.L-亮氨酸和一种非代谢类似物可激活胰岛谷氨酸脱氢酶。
Nature. 1980 Nov 13;288(5787):187-9. doi: 10.1038/288187a0.
5
The quantitative determination of phenylalanine hydroxylase in rat tissues. Its developmental formation in liver.大鼠组织中苯丙氨酸羟化酶的定量测定。其在肝脏中的发育形成。
Biochem J. 1972 May;127(4):669-74. doi: 10.1042/bj1270669.
6
The preparation of, and studies on, free cell suspensions from mouse pancreatic islets.小鼠胰岛游离细胞悬液的制备及研究
Diabetologia. 1974 Oct;10(5):431-8. doi: 10.1007/BF01221634.
7
Diabetes mellitus--a disorder of cellular information transmission?糖尿病——一种细胞信息传递紊乱疾病？
Horm Metab Res. 1970 Jul;2(4):246-9. doi: 10.1055/s-0028-1095082.
8
In vitro stimulation of insulin release by non-metabolizable, transport-specific amino acids.非代谢性、转运特异性氨基酸对胰岛素释放的体外刺激作用。
Biochim Biophys Acta. 1971 Aug 13;241(2):341-8. doi: 10.1016/0005-2736(71)90034-4.
9
Effects of possible beta-cell membrane label, metahexamide-isothiocyanate, on insulin release.可能的β细胞膜标记物异硫氰酸甲磺环己脲对胰岛素释放的影响。
Horm Metab Res. 1979 Feb;11(2):104-6. doi: 10.1055/s-0028-1092689.
10
Studies on the role of beta-cell metabolism in the insulinotropic effect of alpha-ketoisocaproic acid.β细胞代谢在α-酮异己酸促胰岛素分泌作用中的角色研究。
Biochim Biophys Acta. 1979 Dec 3;588(2):211-18. doi: 10.1016/0304-4165(79)90204-6.

3-苯丙酮酸诱导分离的胰岛释放胰岛素的机制。

Mechanism of 3-phenylpyruvate-induced insulin release from isolated pancreatic islets.

作者信息

Panten U, Langer J

出版信息

Biochem J. 1981 Aug 15;198(2):353-6. doi: 10.1042/bj1980353.

DOI:10.1042/bj1980353
PMID:7034729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163255/
Abstract

3-Phenylpyruvate evoked a monophasic insulin release from perifused mouse islets. L-Phenylalanine was not an insulin secretagogue and was oxidized by islets at a very low rate, suggesting that 3-phenylpyruvate does not trigger insulin release by enhancing production of reducing equivalents. Moreover, allosteric activation of glutamate dehydrogenase does not play a role in 3-phenylpyruvate-induced insulin secretion.

摘要

3-苯丙酮酸可引起经灌流的小鼠胰岛释放单相胰岛素。L-苯丙氨酸不是胰岛素促分泌剂，且胰岛对其氧化速率极低，这表明3-苯丙酮酸并非通过增强还原当量的产生来触发胰岛素释放。此外，谷氨酸脱氢酶的变构激活在3-苯丙酮酸诱导的胰岛素分泌中不起作用。