3-苯丙酮酸诱导分离的胰岛释放胰岛素的机制。
Mechanism of 3-phenylpyruvate-induced insulin release from isolated pancreatic islets.
作者信息
Panten U, Langer J
出版信息
Biochem J. 1981 Aug 15;198(2):353-6. doi: 10.1042/bj1980353.
Abstract
3-Phenylpyruvate evoked a monophasic insulin release from perifused mouse islets. L-Phenylalanine was not an insulin secretagogue and was oxidized by islets at a very low rate, suggesting that 3-phenylpyruvate does not trigger insulin release by enhancing production of reducing equivalents. Moreover, allosteric activation of glutamate dehydrogenase does not play a role in 3-phenylpyruvate-induced insulin secretion.
摘要
3-苯丙酮酸可引起经灌流的小鼠胰岛释放单相胰岛素。L-苯丙氨酸不是胰岛素促分泌剂，且胰岛对其氧化速率极低，这表明3-苯丙酮酸并非通过增强还原当量的产生来触发胰岛素释放。此外，谷氨酸脱氢酶的变构激活在3-苯丙酮酸诱导的胰岛素分泌中不起作用。
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