Nishida M, Kawakatsu H, Komatsu H, Ishiwari K, Tamai M, Tsunamoto K, Kasubuchi Y, Sawada T
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Acta Paediatr Jpn. 1998 Oct;40(5):424-6. doi: 10.1111/j.1442-200x.1998.tb01961.x.
Measuring urinary beta 2 microglobin (B2M) and N-acetyl-beta-D-glucosaminidase (NAG) excretion is widely used as a valuable clinical tool in assessing renal tubular lesions. However, few data are available on normal values for urinary excretion of B2M and NAG in infancy.
Urinary B2M and NAG were measured in healthy infants. The logarithmic values of urinary B2M, NAG, B2M/creatinine ratio and NAG/creatinine ratio were distributed almost normally and reference ranges were calculated from the logarithms of the observed values.
The levels of urinary B2M and B2M/creatinine ratio were highest in the 1-month-old group, followed by a decrease during the first 3 months. Urinary B2M excretions in the 3-month-old group showed rather lower levels than those of the 12-month-old and 36-month-old groups. Although urinary NAG excretions were almost constant throughout all groups, urinary NAG/creatinine ratio decreased gradually until 3 years of age.
We suggest that these reference ranges are of importance in evaluating tubular damage due to a variety of renal diseases in infancy.
检测尿β2微球蛋白（B2M）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）排泄量作为评估肾小管损伤的一项重要临床指标被广泛应用。然而，关于婴儿期尿B2M和NAG排泄量的正常值数据却很少。
对健康婴儿的尿B2M和NAG进行检测。尿B2M、NAG、B2M/肌酐比值和NAG/肌酐比值的对数值分布基本呈正态分布，并根据观察值的对数计算参考范围。
1月龄组尿B2M和B2M/肌酐比值水平最高，随后在头3个月下降。3月龄组尿B2M排泄量低于12月龄和36月龄组。虽然所有组的尿NAG排泄量几乎恒定，但尿NAG/肌酐比值在3岁前逐渐下降。
我们认为这些参考范围对于评估婴儿期各种肾脏疾病所致肾小管损伤具有重要意义。
