Rubin J, Humphries J, Smith G, Bower J
Am J Kidney Dis. 1983 Nov;3(3):205-8. doi: 10.1016/s0272-6386(83)80063-8.
There are few studies investigating whether antibiotics added to 30% glucose concentrate preserve their activity in the delivered dialysate. Using a Drake-Willock proportioning system, samples were obtained from the "to" patient path at ten minutes after starting and at four hours. Samples were tested for minimal inhibitory dilution (MID) against Escherichia coli and Staphylococcus aureus. Antibiotics evaluated included amikacin, tobramycin, gentamicin, cephalothin, cefamandole, moxalactam, ampicillin, penicillin, carbenicillin, and vancomycin. In all antibiotics studied, similar MIDs were obtained at the ten-minute and four-hour samples. Compared to saline, dialysate significantly impaired the antibiotic activity (a difference of two or more tube dilutions) of all antimicrobial agents except amikacin and vancomycin.
很少有研究调查添加到30%葡萄糖浓缩液中的抗生素在透析液输送过程中是否能保持其活性。使用德雷克 - 威洛克配量系统，在开始后十分钟和四小时从“到”患者端路径采集样本。对样本进行针对大肠杆菌和金黄色葡萄球菌的最低抑菌稀释度（MID）测试。评估的抗生素包括阿米卡星、妥布霉素、庆大霉素、头孢噻吩、头孢孟多、莫拉卡坦、氨苄西林、青霉素、羧苄西林和万古霉素。在所有研究的抗生素中，十分钟和四小时样本的MID相似。与生理盐水相比，透析液显著损害了除阿米卡星和万古霉素之外所有抗菌药物的抗生素活性（相差两个或更多试管稀释度）。
