Sewell D L, Golper T A, Brown S D, Nelson E, Knower M, Kimbrough R C
Am J Kidney Dis. 1983 Nov;3(3):209-12. doi: 10.1016/s0272-6386(83)80064-x.
The antimicrobial activity of ampicillin, azlocillin, cefotaxime, cephapirin, clindamycin, mezlocillin, nafcillin, piperacillin, tobramycin, and vancomycin was tested in peritoneal dialysate at room temperature for 24 hours and 48 hours. All of the antimicrobial agents were active at 24 hours. The bioactivity of cefotaxime, nafcillin, and vancomycin declined 15% to 20% after 48 hours (P less than 0.001). The addition of heparin or insulin did not affect the activity of any of the study drugs. The combination of cephapirin and tobramycin remained bioactive for 24 hours at room temperature and 35 degrees C. The preparation of drug-dialysate solution every one to two days is feasible for the treatment of peritonitis in patients on continuous ambulatory or continuous cycled peritoneal dialysis.
在室温下，对氨苄西林、阿洛西林、头孢噻肟、头孢匹林、克林霉素、美洛西林、萘夫西林、哌拉西林、妥布霉素和万古霉素在腹膜透析液中的抗菌活性进行了24小时和48小时的测试。所有抗菌药物在24小时时均有活性。48小时后，头孢噻肟、萘夫西林和万古霉素的生物活性下降了15%至20%（P小于0.001）。添加肝素或胰岛素不影响任何一种研究药物的活性。头孢匹林和妥布霉素的组合在室温和35摄氏度下24小时内仍保持生物活性。对于持续非卧床腹膜透析或持续循环腹膜透析的患者，每1至2天制备一次药物 - 透析液溶液用于治疗腹膜炎是可行的。
