抗菌剂在腹膜透析液中的稳定性。
Stability of antimicrobial agents in peritoneal dialysate.
作者信息
Sewell D L, Golper T A
出版信息
Antimicrob Agents Chemother. 1982 Mar;21(3):528-9. doi: 10.1128/AAC.21.3.528.
Abstract
The stability of cephapirin, gentamicin, penicillin G, nafcillin, ticarcillin, and vancomycin was tested in peritoneal dialysate at 25 degrees C for 24 h. All of the antimicrobial agents were stable except penicillin G, which lost 25% of activity over 24 h (P less than 0.01). The once-daily preparation of drug-dialysate solution is feasible for the treatment of peritonitis in patients on continuous ambulatory peritoneal dialysis.
摘要
在25摄氏度下，将头孢匹林、庆大霉素、青霉素G、萘夫西林、替卡西林和万古霉素置于腹膜透析液中测试24小时的稳定性。除青霉素G外，所有抗菌药物均稳定，青霉素G在24小时内活性丧失25%（P<0.01）。对于持续非卧床腹膜透析患者的腹膜炎治疗，每日一次的药物 - 透析液溶液制剂是可行的。
相似文献
1
Stability of antimicrobial agents in peritoneal dialysate.
Antimicrob Agents Chemother. 1982 Mar;21(3):528-9. doi: 10.1128/AAC.21.3.528.
2
Stability of single and combination antimicrobial agents in various peritoneal dialysates in the presence of insulin and heparin.
Am J Kidney Dis. 1983 Nov;3(3):209-12. doi: 10.1016/s0272-6386(83)80064-x.
3
Prolonged stability of antimicrobial activity in peritoneal dialysis solutions.
Perit Dial Int. 2003 Jan-Feb;23(1):58-62.
4
Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (STAB Study).
Perit Dial Int. 2016 Jul-Aug;36(4):421-6. doi: 10.3747/pdi.2015.00062. Epub 2015 Oct 22.
5
Stability and Compatibility of Antibiotics in Peritoneal Dialysis Solutions Applied to Automated Peritoneal Dialysis in The Pediatric Population.
Perit Dial Int. 2016;36(6):676-679. doi: 10.3747/pdi.2015.00018. Epub 2016 May 4.
6
Small and middle molecular weight solute clearance in nocturnal intermittent peritoneal dialysis.
Perit Dial Int. 1999 Nov-Dec;19(6):534-9.
7
Pharmacokinetics of intraperitoneal cefazolin and gentamicin in empiric therapy of peritonitis in continuous ambulatory peritoneal dialysis patients.
Perit Dial Int. 2001 Nov-Dec;21(6):587-94.
8
[Peritonitis in continuous ambulatory peritoneal dialysis. Culture of peritoneal dialysate fluid].
Ugeskr Laeger. 1996 Apr 29;158(18):2538-41.
9
Antibiotic activity in peritoneal dialysate.
Am J Kidney Dis. 1983 Nov;3(3):205-8. doi: 10.1016/s0272-6386(83)80063-8.
引用本文的文献
1
Vancomycin disposition during continuous ambulatory peritoneal dialysis: a pharmacokinetic analysis of peritoneal drug transport.
Antimicrob Agents Chemother. 1985 Apr;27(4):578-82. doi: 10.1128/AAC.27.4.578.
2
Drug therapy in patients undergoing continuous ambulatory peritoneal dialysis. Clinical pharmacokinetic considerations.
Clin Pharmacokinet. 1990 Feb;18(2):104-17. doi: 10.2165/00003088-199018020-00002.
本文引用的文献
1
A comparison of continuous ambulatory peritoneal dialysis in diabetic and nondiabetic patients.
Am J Kidney Dis. 1981 Jul;1(1):15-23. doi: 10.1016/s0272-6386(81)80006-6.
2
Peritonitis during continuous ambulatory peritoneal dialysis.
Ann Intern Med. 1980 Jan;92(1):7-13. doi: 10.7326/0003-4819-92-1-7.
3
Stability of parenteral solutions of sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride.
Am J Hosp Pharm. 1971 Oct;28(10):760-3.
4
Stability of antibiotics in parenteral solutions.
Pediatrics. 1972 Jan;49(1):22-9.
Zotero 插件