Gridnev V A, Livkina E G
Antibiotiki. 1983 Sep;28(9):671-5.
The pathogenicity level of antibiotic sensitive and streptomycin resistant strains of S. typhimurium, S. paratyphi B and S. kottbus changed under the effect of identical R plasmids more frequently in contrary directions. The conjugative plasmids of antibiotic resistance widened the ranges of the virulence changes in the Salmonella serovars for albino mice. It was found that 7 out of 8 plasmids studied significantly decreased and increased the virulence of the antibiotic sensitive Salmonella strains. As a rule, R plasmids of various origin decreased the virulence of all the tested streptomycin chromosome resistant causative agents of salmonellosis.
鼠伤寒沙门氏菌、副伤寒乙沙门氏菌和科特布斯沙门氏菌的抗生素敏感及链霉素抗性菌株的致病性水平，在相同R质粒的作用下，更频繁地朝相反方向变化。抗生素抗性的接合质粒拓宽了沙门氏菌血清型对白化小鼠毒力变化的范围。研究发现，所研究的8种质粒中有7种显著降低和增加了抗生素敏感型沙门氏菌菌株的毒力。通常，各种来源的R质粒会降低所有测试的链霉素染色体抗性沙门氏菌病病原体的毒力。
