Printz M P, Healy D P
Clin Exp Hypertens A. 1983;5(7-8):1037-46. doi: 10.3109/10641968309048840.
Angiotensinogen was measured in the brain and cerebrospinal fluid (CSF) of spontaneously hypertensive rat (SHR) and the normotensive Wistar-Kyoto strain at 4, 7 and 16 weeks of age. Levels of angiotensinogen were elevated in a number of areas of SHR, primarily in the 4 and 7 week old animals. CSF levels did not correlate with the brain levels. These results suggest that the regulation of the brain angiotensin system maybe altered during the development of hypertension.
在4周、7周和16周龄的自发性高血压大鼠（SHR）及血压正常的Wistar-Kyoto品系大鼠的大脑和脑脊液（CSF）中检测血管紧张素原。SHR多个脑区的血管紧张素原水平升高，主要出现在4周龄和7周龄的动物中。脑脊液水平与大脑水平不相关。这些结果表明，高血压发展过程中大脑血管紧张素系统的调节可能发生改变。
