Ueno N, Yoshida K, Hirose S, Yokoyama H, Uehara H, Murakami K
Hypertension. 1984 Nov-Dec;6(6 Pt 1):931-3. doi: 10.1161/01.hyp.6.6.931.
This paper describes the first case of an angiotensinogen-producing tumor. The tumor obtained from a hypertensive patient was examined for its renin and angiotensinogen contents. Renin activity was undetectable; however, the angiotensinogen level was extremely high compared with the levels in the tissue surrounding the hepatoma. The presence of angiotensinogen immunoreactivity in the tumor cells was demonstrated by immunohistochemical staining with an angiotensinogen anti-serum. The plasma level of angiotensinogen was also markedly elevated. These results strongly suggest that the hepatoma was an angiotensinogen-producing tumor.
本文描述了首例产生血管紧张素原的肿瘤。对一名高血压患者的肿瘤进行了肾素和血管紧张素原含量检测。未检测到肾素活性；然而，与肝癌周围组织中的水平相比，血管紧张素原水平极高。用血管紧张素原抗血清进行免疫组化染色，证实肿瘤细胞中存在血管紧张素原免疫反应性。血管紧张素原的血浆水平也显著升高。这些结果有力地表明，该肝癌是一种产生血管紧张素原的肿瘤。
