Everett B A, Kusske J A, Rush J L, Pribram H W
Surg Neurol. 1978 Mar;9(3):157-63.
Two patients with cryptococcal infection of the central nervous system are described. The first presented with signs of an intracranial mass and was subsequently shown to have two lesions within the brain which were later identified as cryptococcal granulomata. Antifungal therapy did not eradicate the lesions; following their excision and continued therapy, the CSF became sterile however. The other patient had signs of a fulminant meningoencephalitis which initially were thought to represent the pathophysiological expression of an expanding brain tumor. These reports are used as a basis to review the various aspects of central nervous system cryptococcosis, particularly as they may relate to the neurosurgeon and the therapy of the disease.
本文描述了两名中枢神经系统隐球菌感染患者。首例患者表现为颅内肿块体征，随后经检查发现脑内有两个病灶，后来被确诊为隐球菌肉芽肿。抗真菌治疗未能消除病灶；在病灶切除并继续治疗后，脑脊液最终转为无菌。另一名患者表现为暴发性脑膜脑炎体征，最初被认为是脑肿瘤扩大的病理生理表现。这些报告作为基础，用以回顾中枢神经系统隐球菌病的各个方面，尤其是与神经外科医生及该疾病治疗相关的方面。
