Hernández A G
Ciba Found Symp. 1983;99:138-56.
In the study of interactions between parasites of Leishmania species and their environment the release of a variety of materials has been detected. Some of these exo-metabolites are species-specific and may be exploited to characterize different leishmanial isolates. As the plasma membrane is the site of interaction between parasite and host it appears that the presence of metabolic products on, and their subsequent release from, the leishmanial cell surface bears a strong relationship to the biological performance of the parasite. The presence of a shedding mechanism in addition to other means of secretion has been shown in Leishmania braziliensis (NR strain). The products shed from the cell surface include glycoproteins and polysaccharide-like complexes. One of these glycoproteins has been purified, and it appears to affect macrophage activity. Because the recognition of these leishmanial metabolic products by antibody is mediated by the glycosylated portion of the secreted macromolecules, a limited repertoire of sugar residues may be common to these types of surface and extra-surface immunogens. Minor changes in the branching or sequence of sugars might constitute a code related to both serotype and biological activity of a given Leishmania strain.
在对利什曼原虫属寄生虫与其环境之间相互作用的研究中，已检测到多种物质的释放。其中一些胞外代谢产物具有种属特异性，可用于鉴定不同的利什曼原虫分离株。由于质膜是寄生虫与宿主相互作用的部位，利什曼原虫细胞表面存在代谢产物以及随后从该表面释放这些产物的现象，似乎与寄生虫的生物学特性密切相关。在巴西利什曼原虫（NR株）中，除了其他分泌方式外，还发现了一种脱落机制。从细胞表面脱落的产物包括糖蛋白和多糖样复合物。其中一种糖蛋白已被纯化，它似乎会影响巨噬细胞的活性。由于抗体对这些利什曼原虫代谢产物的识别是由分泌的大分子糖基化部分介导的，这些类型的表面和表面外免疫原可能具有有限的一组共同糖残基。糖分支或序列的微小变化可能构成与给定利什曼原虫菌株血清型和生物学活性相关的密码。
