Propping P
Hum Genet. 1983;65(1):1-10. doi: 10.1007/BF00285021.
There is overwhelming empirical evidence for the influence of genetic factors in the etiology of schizophrenic psychoses. An appreciable and still increasing number of exogenous factors have been known for decades that are capable of inducing psychoses that present as "schizophrenia" or are more or less similar to it. In this article, genetic disorders--chromosomal abnormalities and Mendelian diseases--are summarized that may be associated with such psychoses. These disorders frequently but not necessarily exhibit additional physical symptoms. Although the majority of schizophrenic psychoses can so far not be explained by exogenous factors or well-defined genetic disorders, the proportion of these etiologies among all cases may be higher than presumed so far, because they evade detection. Data from the literature are discussed in the light of Karl Bonhoeffer's early concept of exogenous reaction types and modern medical genetics.
有大量实证证据表明遗传因素在精神分裂症性精神病的病因学中具有影响。几十年来，人们已经知道有相当数量且仍在增加的外源性因素能够诱发表现为“精神分裂症”或与其或多或少相似的精神病。在本文中，总结了可能与这类精神病相关的遗传性疾病——染色体异常和孟德尔疾病。这些疾病常常但不一定会表现出其他躯体症状。尽管目前大多数精神分裂症性精神病无法用外源性因素或明确的遗传性疾病来解释，但这些病因在所有病例中所占的比例可能比迄今推测的要高，因为它们难以被检测到。本文根据卡尔·博恩霍费尔早期的外源性反应类型概念和现代医学遗传学对文献数据进行了讨论。
