Macfarlane J T, Finch R G, Ward M J, Rose D H
J Infect. 1983 Sep;7(2):111-7. doi: 10.1016/s0163-4453(83)90464-4.
In a double blind trial erythromycin was compared with a combination of ampicillin and amoxycillin for treating adults admitted to hospital with primary pneumonia. The clinical course of 42 patients treated with ampicillin and amoxycillin was similar to that of the 49 in the erythromycin group. Fall in temperature, symptomatic recovery and radiographic improvement were similar (two-thirds made an uncomplicated recovery). Infusion-related phlebitis was more common with erythromycin. Otherwise adverse reactions were unusual. The outcome was related principally to the cause of the pneumonia with bacteraemic/antigenaemic pneumococcal pneumonia, Legionnaires' disease, other bacterial pneumonias and psittacosis having a poor prognosis. Both forms of antibiotic therapy gave similar results but we suggest that a combination of erythromycin with ampicillin may be logical initial treatment for severe pneumonia of unknown cause.
在一项双盲试验中，将红霉素与氨苄西林和阿莫西林的联合用药进行比较，用于治疗因原发性肺炎入院的成人患者。42例接受氨苄西林和阿莫西林治疗的患者的临床病程与红霉素组的49例相似。体温下降、症状恢复和影像学改善情况相似（三分之二的患者顺利康复）。与输注相关的静脉炎在使用红霉素时更为常见。除此之外，不良反应并不常见。结果主要与肺炎病因有关，菌血症/抗原血症性肺炎球菌肺炎、军团病、其他细菌性肺炎和鹦鹉热预后较差。两种抗生素治疗方法的结果相似，但我们建议，对于病因不明的重症肺炎，红霉素与氨苄西林联合用药可能是合理的初始治疗方案。
