Fraser D W, Wachsmuth I, Bopp C, Feeley J C, Tsai T F
Lancet. 1978 Jan 28;1(8057):175-8. doi: 10.1016/s0140-6736(78)90611-6.
Erythromycin and rifampicin (rifampin) were able to prevent death of guineapigs given intraperitoneal injections of the agent causing legionnaires' disease. Penicillin, chloramphenicol, tetracycline, and gentamicin showed no significant effect. On the basis of clinical experience and experimental observations, erythromycin is recommended for patients suspected to have legionnaires' disease. Combined therapy with erythromycin and rifampicin may be justified in patients with confirmed legionnaires' disease who are not responding to erythromycin alone or as part of a controlled antibiotic trial among suspected cases during an outbreak of legionnaires' disease.
红霉素和利福平能够预防给豚鼠腹腔注射引起军团病的病原体后导致的死亡。青霉素、氯霉素、四环素和庆大霉素未显示出显著效果。基于临床经验和实验观察结果，对于疑似患有军团病的患者，推荐使用红霉素。对于确诊为军团病但单独使用红霉素无反应的患者，或者作为军团病暴发期间疑似病例对照抗生素试验的一部分，红霉素与利福平联合治疗可能是合理的。
