Passariello N, Giugliano D, Quatraro A, Consoli G, Sgambato S, Torella R, D'Onofrio F
Metabolism. 1983 Dec;32(12):1163-5. doi: 10.1016/0026-0495(83)90065-3.
Plasma glucose, insulin, glucagon, and growth hormone responses to intravenous glucose stimulation were investigated in 15 heroin-dependent men and in 15 control subjects matched for age, sex, and weight. Although the fasting concentrations of insulin, glucagon, and GH were significantly higher in the heroin addicts, they had markedly reduced plasma insulin responses to intravenous glucose (acute insulin response, calculated as the mean change in insulin levels over 3 to 10 minutes: 10 +/- 5 microU/mL in the addicts v 44 +/- 9 microU/mL in the controls, P less than 0.001) and glucose utilization rates in the diabetic range (KG: 0.96 +/- 0.09%/min in the addicts v 1.65 +/- 0.10%/min in the controls, P less than 0.01). These results show that chronic heroin administration produces a state of fasting hyperinsulinemia even in the absence of obesity, glucose intolerance, and a marked reduction of the first phase of insulin secretion. A possible role for endogenous opiates in the pathogenesis of non-insulin-dependent diabetes is hypothesized.
对15名海洛因依赖男性及15名年龄、性别和体重相匹配的对照者进行了静脉注射葡萄糖刺激后的血浆葡萄糖、胰岛素、胰高血糖素和生长激素反应研究。尽管海洛因成瘾者的空腹胰岛素、胰高血糖素和生长激素浓度显著更高，但他们对静脉注射葡萄糖的血浆胰岛素反应明显降低（急性胰岛素反应，计算为3至10分钟内胰岛素水平的平均变化：成瘾者为10±5微单位/毫升，对照组为44±9微单位/毫升，P<0.001），且葡萄糖利用率处于糖尿病范围（KG：成瘾者为0.96±0.09%/分钟，对照组为1.65±0.10%/分钟，P<0.01）。这些结果表明，即使在没有肥胖、葡萄糖不耐受和胰岛素分泌第一阶段显著降低的情况下，长期使用海洛因也会导致空腹高胰岛素血症状态。推测内源性阿片类物质在非胰岛素依赖型糖尿病发病机制中可能起作用。
