Gozashti Mohammad Hossein, Yazdi Farzaneh, Salajegheh Pouria, Dehesh Mohammad Moein, Divsalar Kouros
Associate Professor, Endocrinologist, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Assistant Professor, Department of Internal Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2015 Winter-Spring;7(1-2):54-9.
Many of lay person believe that opium lowers blood glucose. However some studies show the opposite results. In this study, we tried to evaluate the effect of opium on blood glucose and insulin resistance.
This comparative study including 53 addicts in case groups who used opium just in the form of smoking and 55 non-addicts in a control group, took part in the study, after proving not to be opium users. After taking blood samples, their fasting blood glucose (FBG), fasting blood insulin and lipid profiles were evaluated. Furthermore, insulin resistance index was analyzed via the homeostatic model assessment of insulin resistance (HOMA-IR) formula with the cut-off points of 7.2 and 7.1.
Age and gender were not significantly different between the groups. There was no significant difference regarding the prevalence of insulin resistance between the two groups, according to the cut-off points of 7.1 and 7.2 (P = 0.196 and P = 0.248, respectively). Mean insulin resistance index was not significantly different between the two groups (P = 0.325). In the case group, fasting blood insulin was considerably lower (P = 0.025) and fasting blood sugar (FBS) was significantly higher (P = 0.016) than the control group.
According to the level of insulin and FBS in addicts, it does not seem that opium has a significant effect on reducing the blood glucose and insulin resistance.
许多外行人认为鸦片能降低血糖。然而，一些研究显示出相反的结果。在本研究中，我们试图评估鸦片对血糖和胰岛素抵抗的影响。
这项比较研究包括53名仅以吸烟形式使用鸦片的成瘾者作为病例组，以及55名经证实非鸦片使用者的非成瘾者作为对照组。采集血样后，评估他们的空腹血糖（FBG）、空腹血胰岛素和血脂谱。此外，通过胰岛素抵抗稳态模型评估（HOMA-IR）公式分析胰岛素抵抗指数，截断点分别为7.2和7.1。
两组之间年龄和性别无显著差异。根据截断点7.1和7.2，两组之间胰岛素抵抗患病率无显著差异（P分别为0.196和0.248）。两组之间的平均胰岛素抵抗指数无显著差异（P = 0.325）。病例组的空腹血胰岛素显著低于对照组（P = 0.025），空腹血糖（FBS）显著高于对照组（P = 0.016）。
根据成瘾者的胰岛素和FBS水平，鸦片似乎对降低血糖和胰岛素抵抗没有显著影响。
