Holloway D S, Zuckerman L, Vagher J P, Mockros L F
Thromb Haemost. 1983 Oct 31;50(3):671-5.
The effects of prostacyclin (PGI2) on mechanical properties of forming clots were investigated by testing human blood samples on a Thrombelastograph. Concentrations greater than 50 ng/ml (blood) caused a biphasic development of clot stiffness. During the first phase, PGI2 partially inhibited the platelet involvement in coagulation causing initial clot formation at a normal time but with reduced clot stiffness. The second phase occurred after neutralization of PGI2 activity and was characterized by recovery of platelet activity to produce a final clot with normal shear modulus. The duration of the inhibitory effects depended on PGI2 concentration and hematocrit. With a normal hematocrit, a PGI2 concentration of 60 ng/ml caused an inhibition for about 40 min whereas a concentration of 100 ng/ml caused inhibition for about 75 min.
通过在血栓弹力图仪上检测人体血液样本，研究了前列环素（PGI2）对正在形成的血凝块力学特性的影响。浓度大于50 ng/ml（血液）会导致血凝块硬度呈双相发展。在第一阶段，PGI2部分抑制血小板参与凝血，使初始血凝块在正常时间形成，但血凝块硬度降低。第二阶段发生在PGI2活性被中和之后，其特征是血小板活性恢复，产生具有正常剪切模量的最终血凝块。抑制作用的持续时间取决于PGI2浓度和血细胞比容。在血细胞比容正常的情况下，PGI2浓度为60 ng/ml时会产生约40分钟的抑制作用，而浓度为100 ng/ml时会产生约75分钟的抑制作用。
